Paralimbic cortex had longer SEEG knee time scales but shorter BOLD time scales than heteromodal cortex in two human cohorts

We tested whether a cortical time scale order transfers between human SEEG and fMRI from separate studies. We used public RAM electrical fits and MICA-MICs BOLD time series. BOLD contrasts used the same named-region sets as the SEEG coverage. Paralimbic minus heteromodal log10 time scale was +0.2107 in 61 SEEG patients (95% person bootstrap range +0.1332 to +0.2925) and -0.3654 in 48 complete BOLD participants (-0.3893 to -0.3422). Both Holm p values were 0.00008 across four planned tests. Resampling both cohorts kept the BOLD range negative. Alternative BOLD estimators, edge removal, and single-region removal retained the opposite mean signs. The heteromodal-to-primary/unimodal contrast was positive in BOLD but uncertain in SEEG. Electrical adjustment for fitted exponent reduced the paralimbic contrast to +0.0643, with a range that included zero. These results show a failure of the tested order to transfer. They do not identify the cause. Epilepsy and memory-task SEEG differ from healthy resting BOLD in cohort, state, frequency, spatial scale, and measurement. The package preserves code, inputs, source hashes, all results, uncertainty draws, figures, and repeat steps. Independent calculations matched 757 selected source fits and the new autocorrelations.

human neuroscience · SEEG · fMRI · time scales · cross-modal comparison · measurement · cortical hierarchy · reproducibility