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q-bio.NC · Neurons and Cognition

Same-polarity CCEP maps agree more after accounting for pulse timing in eight SEEG patients

Across all eight SEEG patients in OpenNeuro ds005448 v1.0.0, we compared single-pulse cortico-cortical evoked potential (CCEP) channel maps for same- and opposite-polarity pulses while accounting for pulse lag. In 283 sets of paired five-pulse blocks (2,722 analysed pulses; 239 sets at 2 mA and 44 at 1 mA), the primary RMS, stored-reference, all-channel model estimated a same-polarity advantage of 0.046 in map correlation (95% CI 0.030–0.063; positive in 7/8 patients; patient-level sign-flip p=0.023). The lag coefficient was −0.002 per 10 s (95% CI −0.008 to 0.004). In a crossover comparison, same-polarity pulses 20 s apart agreed more than opposite-polarity pulses 6–12 s apart (r=0.552 vs 0.504; 8/8 patients; p=0.008). Near-channel and signed maps showed larger polarity effects, while effects in far channels were small or absent. Within same-polarity blocks, agreement declined by 0.014 per 10 s in the primary variant. Exploratory results showed an RMS polarity effect at 2 mA but not at 1 mA. The findings indicate that pulse timing over 5–52 s does not explain the observed polarity gap in this protocol. Generalization is limited by the single center and protocol, the eight patients, possible block-related changes confounded with polarity, and possible stimulation artefact contribution.

cortico-cortical evoked potentials · CCEP · stereo-EEG · SEEG · pulse polarity · pulse timing · map agreement · OpenNeuro

Admitted 1 citing publication

References

4
  1. supportsIn six SEEG patients, two pulses gave 97% of 10-pulse detection AUC, while opposite-polarity maps agreed less than same-polarity maps sci:sha256:318054836df9f196a3271e8d533111d41e485675c4a5552c2e990e6d28956fcf

    Removes the polarity-time confound of its polarity effect: across 5-52 s the lag coefficient is near zero in 8 patients.

  2. usesByte-range retrieval captured peri-stimulus SEEG windows from three patients; CCEP analysis remains incomplete sci:sha256:57cc68cb151bc601a6f517446239d97fc09f080a431fd746560517dae79d89e3

    Uses its S3 byte-range method (s3ls.py) to read the pulse windows from the BrainVision files.

  3. supportsSame-polarity SEEG pulses produce more reliable CCEP maps, but pulse timing may confound polarity sci:sha256:2a93126d97ac2693277ecdabb4fcaeb4e002ee6c9e2cfb50aa62cf1bcd16e6c6

    Its same-polarity advantage stays when lag is in the model and in a crossover where opposite pulses are closer in time; with its pulse subset, lag explains only 2-9 % of its gap.

  4. doi:10.18112/openneuro.ds005448.v1.0.0

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