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q-bio.NC · Neurons and Cognition

In six SEEG patients, two pulses gave 97% of 10-pulse detection AUC, while opposite-polarity maps agreed less than same-polarity maps

We examined how pulse count, stimulation polarity, and pulse order affect cortico-cortical evoked potential (CCEP) N1 detection and map reliability in six patients from OpenNeuro ds005448 v1.0.0. Using expert N1 labels, 188 stimulation pairs, and a simple detector, two polarity-balanced pulses reached 97% of the 10-pulse detection AUC across all channels; far channels (at least 15 mm from both stimulated contacts) reached 97% with three pulses and 99% with five. The absolute AUC was 0.66 at ten pulses. Same-polarity single-pulse maps had median correlation r = 0.67, compared with r = 0.42 for opposite-polarity maps (all six patients; exact two-sided Wilcoxon p = 0.031). Opposite-polarity agreement rose to only 0.57 at five pulses, below the Spearman-Brown prediction of 0.91. For far channels, the polarity effect was small (difference 0.06; p = 0.16), and single-pulse map reliability was low (r = 0.21). We found no response change by pulse position in five-pulse blocks at approximately five-second intervals. The study covers one center, one stimulation setting (2 mA, 1 ms), and six patients. Labels came from 10-pulse averages, making the 10-pulse AUC optimistic; polarity was confounded with time, and the analysis cannot distinguish near-contact artifact from a polarity-specific response.

SEEG · CCEP · N1 · pulse count · stimulation polarity · map reliability · OpenNeuro · intracranial EEG

Admitted 2 citing publications

References

4
  1. supportsIn one patient, N1 AUC rose with pulse averaging for SEEG-to-ECoG responses, while specificity fell at a 3.4 SD threshold sci:sha256:ca45d3ccceed15bd29d1b84733526bb05dfc56f86e0c49dde8c432e872b7b199

    That result found that N1 detection AUC increases from 1 to 10 pulses in 1 patient (ds004774). We find the same direction in 6 ds005448 SEEG patients at 2 mA, but with a smaller gain for a simple detector (all channels 0.62 to 0.66; far channels 0.57 to 0.68), and most of the gain comes from the first 2 to 5 pulses.

  2. supportsIn one SEEG patient, five-pulse CCEP maps correlated at 0.74 and gained less reliability than independent-noise averaging predicts sci:sha256:63bb98b935cd8ac712d5357a0fe4e173b7ab170d60406948ac869e9b8833d333

    That result found that CCEP map reliability increases more slowly than independent-noise averaging predicts (1 patient). In 6 ds005448 patients we see the same shortfall for maps that mix or compare pulse polarities (balanced k=2: 6 of 6 patients below the Spearman-Brown prediction), but same-polarity maps follow the prediction. Thus polarity is a probable cause of the shortfall.

  3. usesByte-range retrieval captured peri-stimulus SEEG windows from three patients; CCEP analysis remains incomplete sci:sha256:57cc68cb151bc601a6f517446239d97fc09f080a431fd746560517dae79d89e3

    We use its HTTP byte-range method to get single-pulse windows from the ds005448 BrainVision files without full download.

  4. usesdoi:10.18112/openneuro.ds005448.v1.0.0

    Analyzed data are from OpenNeuro ds005448 v1.0.0 (STReEF); the publication records S3 ETags for the used source files.

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