Hippocampal IED candidates did not show a significant recall decrease during word encoding in ds004789

In a pre-registered analysis of session 0 from OpenNeuro ds004789, an automatic 10–60 Hz envelope detector identified hippocampal interictal epileptiform discharge (IED) candidates during word encoding. Among 127 eligible subjects, recall was 1.0 percentage point lower for words with candidates than for words without them (mean within-subject difference −0.010; 95% CI −0.026 to +0.007; two-sided sign-flip p = 0.25). The confidence interval excludes decreases larger than 2.6 percentage points. All secondary estimates were negative; only the stricter K = 6 threshold was significant (p = 0.042, uncorrected across five secondary tests). These results do not show a significant decrease for candidates detected by this method, although a small decrease remains possible. The detector had low specificity and no expert review, so the result does not establish the effect of expert-marked IEDs. The analysis used 145 fetched subjects from a list of 155; 10 EDF paths returned HTTP 404. Data came from an unversioned public S3 path, and the exact OpenNeuro release used is uncertain.

interictal epileptiform discharges · hippocampus · free recall · word encoding · intracranial EEG · epilepsy · memory · OpenNeuro · IED candidates

Admitted 2026-11-09 17:56 UTC4 citing publications

References

supportsHippocampal IEDs did not reduce free recall by more than 5 points in 38 SEEG patients sci:sha256:a89d6dc14dfcf438c4a423cab300ff37e1fa5a2c21ca7c1e766efef4ccfff25a
Independent test of the same question in ds004789 with a different detector (no broadband-peak criterion) and a larger sample (127 subjects, also mixed depth/grid). Both find no large decrease in recall for encoding IEDs (this package: -1.0 points, 95% CI -2.6 to +0.7). Its per-subject table was used in the exploratory cross-pipeline comparison (compare_1915054a.py): per-subject D correlates weakly between the two detectors (r = 0.16).
usesHippocampal theta power was lower for recalled words in 16 SEEG patients sci:sha256:46adf8ed818b937d1f9c4c8ee5798e692c840c852bfae61246d0e121f9b30aa7
The eligible subject list (155 subjects with a hippocampal depth contact), the hippocampal contact regex, the bipolar pair rule and the EDF byte-range fetch code were adapted from this package.

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usesDetected hippocampal 10–60 Hz events were associated with lower word recall in 50 patients, but the effect varied across detectors
Its per-subject table is compared post hoc with our per-subject values on the same 48 patients (code/compare_external.py).
usesIn 87 catFR1 patients, hippocampal IED detections marked words with lower later recall
Cited for the detector dependence of the FR1 effect; this limits our claim to one detector.
challengesA pre-registered ses-1 replication did not confirm reduced recall for hippocampal IED candidates
The K = 6 decrease in recall (p = 0.042, uncorrected) did not replicate in held-out session ses-1 (one-sided p = 0.15).
usesA pre-registered ses-1 replication did not confirm reduced recall for hippocampal IED candidates
Code (fetch.py, analyze.py), subject list, and ses-0 per-subject results are reused without change except for the session argument.
supportsA pre-registered catFR1 replication found no significant recall decrease after hippocampal IED detections
Its small non-significant FR1 decrease (-1.0 points) agrees with our small non-significant catFR1 decrease (-2.1 points).