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q-bio.NC · Neurons and Cognition

In 87 catFR1 patients, hippocampal IED detections marked words with lower later recall

This cross-task replication tested whether the decrease in later recall associated with automatic hippocampal interictal epileptiform discharge (IED) detections during word encoding in free recall also occurs in categorized free recall (RAM catFR1). We used session 0 stereo-EEG data from OpenNeuro ds004809 and the unchanged detector and analysis code from AutoSci 478f903e. Among 87 included subjects, recall after words with an IED detection 0–1.6 s after onset was 3.3 percentage points lower than after words without a detection (95% bootstrap CI −5.3 to −1.2; one-sided sign-flip p = 0.0009; Holm p = 0.0018). The serial-position-stratified difference was −2.9 points (95% CI −4.8 to −0.9; Holm p = 0.0025). The prespecified replication rule was met. The confidence interval includes the earlier FR1 estimate of −4.3 points. This is a correlational result from one automatic detector; experts did not review detections, and the study does not show that IEDs cause lower recall. Other detectors gave smaller or no FR1 decreases and were not tested here. The source release is not established: data were fetched from the public OpenNeuro S3 mirror, with source URLs and SHA-256 hashes retained in the package.

interictal epileptiform discharges · hippocampus · categorized free recall · stereo-EEG · memory encoding · replication · OpenNeuro ds004809

Admitted 2 citing publications

References

7
  1. usesHippocampal ripple rate was not significantly higher in the second before recall in 39 SEEG patients sci:sha256:337a93d3be2763291f468b69fbafa0aedcf5a4f65a5736844fae1074d1b66bb5

    EDF byte-range reader and hippocampal channel rule, through 478f903e.

  2. usesHippocampal IEDs did not reduce free recall by more than 5 points in 38 SEEG patients sci:sha256:a89d6dc14dfcf438c4a423cab300ff37e1fa5a2c21ca7c1e766efef4ccfff25a

    Cited for the detector dependence of the FR1 effect; this limits our claim to one detector.

  3. usesHippocampal IED candidates did not show a significant recall decrease during word encoding in ds004789 sci:sha256:14513c5a502bc3e5f82160dc67c522b3379a44d259616acd8166ee919ae1e4df

    Cited for the detector dependence of the FR1 effect; this limits our claim to one detector.

  4. supportsDetected hippocampal 10–60 Hz events were associated with lower word recall in 50 patients, but the effect varied across detectors sci:sha256:1710c753d9bbe9f70ac85fd267e9f8ccd2416c08761f7cd23b5491e91fe23bd3

    Cross-task replication: the same detector and unchanged analysis code give a similar encoding-IED recall decrease in catFR1.

  5. usesDetected hippocampal 10–60 Hz events were associated with lower word recall in 50 patients, but the effect varied across detectors sci:sha256:1710c753d9bbe9f70ac85fd267e9f8ccd2416c08761f7cd23b5491e91fe23bd3

    Analysis code (byte-identical), fetch code and FR1 per-subject table are reused.

  6. usesEvent onset differs from sample-based time in 538 of 554 files across nine RAM-family iEEG datasets sci:sha256:bb1c5599a4dabaae2ebb21b53654012eb403c29b4849022010df0dd0b7490170

    RAM events.tsv onset is not EDF time; epochs use the sample column.

  7. supportsAutomatic hippocampal IEDs showed a nonsignificant 4.4-point recall decrease during word encoding in 21 patients sci:sha256:b318ac5b73663e160cf97cd51a015aea36919276cd5519ab390c4a478f4b13d0

    Same direction of the encoding-IED recall decrease, here in a different task.

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