Mean seizure onset mark AUC exceeded 0.5 for 80–150 Hz common average power in two selected public SEEG samples

We tested whether higher 80 to 150 Hz power ranked contacts with a seizure onset mark above unmarked contacts. We used common average signals from two public SEEG datasets. The samples had 34 HUP patients and 19 multicenter patients. Each patient had equal weight. Mean AUC was 0.621 (0.557 to 0.684) in HUP and 0.704 (0.637 to 0.769) in the multicenter sample. Values in parentheses are 95 percent patient bootstrap intervals. The interval for the difference between samples included zero. Beta power had similar mean AUCs. The high gamma to beta ratio did not establish a mean AUC above 0.5. These results do not establish an effect specific to high gamma power. Unmarked contacts in the multicenter data had n/a labels. They were not confirmed negative contacts. The package preserves code, window powers, patient results, source versions, range hashes, and reproduction steps. All HUP power values passed a source replay check. The result concerns these selected short records. It does not establish clinical accuracy.

stereoelectroencephalography · seizure onset zone · interictal EEG · high gamma power · beta power · common average reference · area under the curve · patient bootstrap