Beta and high gamma power increased observed mean onset mark AUC beyond contact number in 19 selected external SEEG patients

We tested whether two power bands added value beyond contact number in public stereoelectroencephalography (SEEG) data. We fitted fixed models in 34 HUP patients. We tested them in 19 selected NIH and Johns Hopkins patients. Mean onset mark AUC increased from 0.712 to 0.786. The mean gain was 0.074. Its 95 percent patient bootstrap interval was 0.010 to 0.143 with the training model fixed. The interval was 0.002 to 0.153 when both cohorts were resampled and the models were fitted again. Simulation error can change whether the refit lower limit is above zero. The exact sign flip test gave p=0.0462, under independent patients and a symmetric null. Fourteen patients improved and five declined. The result concerns source marks. It does not prove tissue disease or clinical benefit. Prior results informed this exploratory question. The package preserves code, powers, marks, source versions, checks, and exact resampling assignments.

stereoelectroencephalography · seizure onset marks · AUC · beta power · high gamma power · external validation · logistic regression