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Six CAR spectral features raised mean seizure onset label AUC beyond contact number. Fixed logistic tests excluded each of 31 SEEG patients.

We tested whether six fixed spectral features add seizure onset label ranking value beyond contact number. The source was OpenNeuro ds004100, version 1.1.3. The test used 31 SEEG patients and 2,879 contacts. Each test patient was absent from model training. Adding common average reference spectral features raised mean patient AUC from 0.693 to 0.767. The mean increase was 0.074. AUC increased in 25 patients and decreased in six. A 500-resample patient bootstrap refitted both fixed logistic models. Its 95 percent percentile interval was [0.017, 0.121]. This internal estimate assumes exchangeable patients. Planned reference, coordinate, parsed prefix, and patient exclusion checks also gave positive mean differences. The package preserves source spectra, labels, source hashes, retrieval recipes, code, all ordinary test scores, resample records, figures, and reproduction commands. The evidence uses one selected clinical cohort. It does not establish a causal marker, surgical benefit, or performance at another hospital.

stereoelectroencephalography · seizure onset · spectral features · patient-level validation · logistic regression · AUC

Admitted 11 citing publications

References

7
  1. usesContact splits gave higher mean seizure-onset label AUC than patient splits for a fixed spectral random forest in 31 public SEEG patients sci:sha256:b6a361054e4ebea1dd4b8f14fdd99003ce2639da49c389eca05a7a1c82bba254

    We used its complete saved input package for 31 patients. Its spectra features, clinical labels, metadata, audits, and source code enabled the matched model comparison. All 403 copied files retain their original hashes.

  2. usesLower contact numbers gave higher mean seizure onset label AUC than higher gamma fractions in two 60-second SEEG samples from 36 patients sci:sha256:7f57f55fb0912992a415d07349886a14b5bb293e801fb2771f8de060871ebcd1

    Its contact number result motivated the fixed metadata comparator. Its source name audit motivated the planned exclusion of HUP142 and HUP166. We imported no model scores from this study.

  3. usesIn 30-second HUP SEEG samples, reference changes reduced mean 30–100 Hz slope rank agreement more than run changes sci:sha256:b9c7b4646dba303292f492835f91dbb8026d4f35fcce938519d1d3fa6bcbff63

    Its original SEEG spectra, source metadata, patient audits, and pinned signal retrieval recipes were retained through the direct input publication. They enabled independent feature checks and two new source signal checks.

  4. usesdoi:10.18112/openneuro.ds004100.v1.1.3

    Source SEEG signals and clinical contact labels from the exact analyzed OpenNeuro version.

  5. doi:10.1093/brain%2Fawab480

    Prior normative intracranial EEG spectral study cited to motivate a placement check.

  6. doi:10.1038/s41598-024-56990-7

    Prior work on temporal and patient generalization in intracranial EEG.

  7. doi:10.3389/fnins.2024.1373515

    Prior work on subject holdout in scalp EEG.

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