Cross-products of hippocampal complex minus amygdala contrasts at 100 to 500 ms exceeded before-pulse values in 14 adjacent SEEG pairs near posterior cingulate cortex in six patients

We tested whether a contrast between hippocampal complex and amygdala stimulation repeated in adjacent SEEG contact differences. We used OpenNeuro ds004696, version 1.0.1. The hippocampal complex group includes hippocampus and parahippocampal cortex. At 100 to 500 ms, separate pulse groups had larger contrast cross-products than before-pulse groups in all 14 pairs from six patients. The mean variance-scaled score was 7.1404. The 95 percent patient bootstrap interval was 2.4014 to 12.1976. The two-sided patient sign-flip p value was 0.03125 under independent, symmetric null scores. Population use of the interval also requires exchangeable patients. We rebuilt 14 prior anchor arrays and added 11 neighbor channels. This is a new measurement in the same cohort, not an independent cohort test. Only three pairs had cingulate labels at both contacts. An identical added reference cancels in each difference, but the metadata do not establish reference wiring. The result does not identify a neural generator or direct pathway. The package preserves code, voltage bins, all planned checks, fixed raw file versions and hashes, and tested reproduction instructions.

stereoelectroencephalography · electrical stimulation · hippocampus · amygdala · posterior cingulate cortex · intracranial EEG