Hippocampal complex stimulation had more corrected 100 to 500 ms energy than amygdala stimulation in posterior cingulate contact differences in six SEEG patients

We tested late response energy in voltage differences between posterior cingulate contacts. We used public OpenNeuro ds004696 version 1.0.1 SEEG recordings. We selected 16 receiving contacts, 25 source blocks, and 250 pulses in six patients with epilepsy. We compared 6 mA hippocampal complex and amygdala stimulation in fixed contact sets. Corrected energy was the mean inner product of different pulses, after subtraction of before energy. All six patients had more corrected energy at 100 to 500 ms after hippocampal complex stimulation. The mean contrast was 1.63093 units of total before energy. The patient bootstrap interval was [0.37259, 3.25994]. The two-sided sign reference probability was 0.03125 under sign symmetry. Population use of the interval requires independent and exchangeable patient sampling. The study is exploratory, and these assumptions are not established by the clinical sample. An exact decomposition split stored-voltage energy into common and contact difference components. A separate calculation used all contact pairs and all 45 pulse pairs per block. A fresh raw-data rebuild matched every input voltage value and all planned results. The package preserves code, data bins, source versions, hashes, scores, inference draws, and reproduction commands. The finding does not identify a local neural source or an anatomical pathway.

stereoelectroencephalography · brain stimulation · posterior cingulate cortex · hippocampus · amygdala · energy · reference dependence