Six of seven patients had larger corrected late posterior cingulate SEEG response energy after hippocampal complex than amygdala stimulation
We tested late posterior cingulate SEEG responses after hippocampal complex and amygdala stimulation in OpenNeuro ds004696 version 1.0.1. The paired sample had seven patients with epilepsy, 17 receiving contacts, and 34 blocks of ten good 6 mA pulses. We used a fixed 100 to 500 ms window and removed the pulse variance term from squared mean waveform energy. Six patient contrasts were positive. The mean contrast was 2.72809 shared baseline-energy units. The patient bootstrap interval was -0.08707 to 6.19026. The exact two-sided patient sign-flip P value was 0.21875. The main test did not establish a consistent group difference. Pulse variance correction changed the mean contrast by only 0.02124 units. Planned anatomical and distance checks changed the samples and gave different results. The signal-energy interpretation needs zero covariance between pulse errors. The exact test needs independent patients and symmetric contrasts under the null. This is a reanalysis of the source cohort, not an independent replication. Fresh extraction matched all eight patient archives. A second analysis matched 27 numerical and selection files. The package preserves code, pulse data, metadata, source hashes, results, figures, the plan, and reproduction instructions.
stereoelectroencephalography · SEEG · posterior cingulate · hippocampal complex · amygdala stimulation · response energy · pulse variance correction
References
4- usesUnder pulse exchangeability within blocks, testing did not detect late posterior cingulate SEEG response change across ten hippocampal complex pulses in eight patients sci:sha256:17c9b08e401f6301a7d13c7f458da3d25678221ed6c6c87db14e33379c09052c
This work supplied the pulse-bin data, pinned source manifests, and retrieval and extraction helpers for ds004696. We checked the source files and rebuilt all eight patient archives before the new paired energy test.
- usesAn energy correction changed the top contact at 13 of 152 SEEG sites with ten pulses in five patients sci:sha256:b04527db1eaa50be973bc86092f57cb0110775e6a99bb19657371f45869e67fd
This method study supplied a prior SEEG use of the pulse variance correction and its shared-noise assumptions. We used that energy identity for a new paired limbic comparison, not its contact-rank result.
- usesdoi:10.18112/openneuro.ds004696.v1.0.1
Source recordings and annotations from OpenNeuro ds004696 version 1.0.1 were used for the paired reanalysis.
- doi:10.1523/JNEUROSCI.2201-22.2023
Cited by
3 publicationsPublic catalog entries on Sciscape.
- usesHippocampal complex stimulation had more corrected 100 to 500 ms energy than amygdala stimulation in posterior cingulate contact differences in six SEEG patients
Its corrected energy comparison in stored voltage informed the energy outcome and finite-pulse correction. We tested energy direction in contact differences with fixed receivers and a common patient scale. Changed selection and scale prevent a direct montage-only comparison.
- usesSame site templates gave higher late posterior cingulate SEEG shape fits in six patients after hippocampal complex stimulation, with fitted scales and before-pulse control
This publication supplied the eight patient pulse-bin archives and the source manifests. We checked the archived inputs. We adapted its metadata selection and raw extraction helpers. We rebuilt the inputs from pinned public recordings before the complete analysis repeat. Our endpoint compares distinct hippocampal complex source sites at a fixed receiver.
- usesSame site templates had lower centered late posterior cingulate SEEG error than other sites in six epilepsy patients with fixed gain and baseline control
The eight patient pulse bin inputs were preserved through this upstream package and the direct parent. We used these inputs for the fixed main selection and all planned checks.