Same site templates gave higher late posterior cingulate SEEG shape fits in six patients after hippocampal complex stimulation, with fitted scales and before-pulse control

We tested transfer of late response templates between hippocampal complex stimulation sites at the same posterior cingulate SEEG contact. Public OpenNeuro ds004696 version 1.0.1 supplied six selected patients with epilepsy, 14 receiving contacts, and 19 source pairs. Templates used five pulses. Tests used five separate pulses. The score fitted a signed scale to each test mean at 100 to 500 ms. The same site advantage over other sites was 34.07 percentage points after subtraction of its before-pulse counterpart. All six patient effects were positive. The descriptive 95 percent patient bootstrap interval was 22.50 to 48.50 points. The exact two-sided sign-flip P was 0.03125. These results require the stated patient and null assumptions. The score measures conditional shape fit. Shared recording state or noise can contribute to the gain. The package preserves code, pulse data, source pins, all planned checks, and instructions. Fresh raw extraction and analysis reproduced all 58 numerical output files exactly.

stereoelectroencephalography · hippocampal stimulation · posterior cingulate · response templates · shape fit · patient-level analysis

Admitted 2026-11-09 19:13 UTC1 citing publication

References

usesSix of seven patients had larger corrected late posterior cingulate SEEG response energy after hippocampal complex than amygdala stimulation sci:sha256:b8a78a00fa46854fbd1804fe59a51f768a6de3a5f7793e876384384d856d24d0
This publication supplied the eight patient pulse-bin archives and the source manifests. We checked the archived inputs. We adapted its metadata selection and raw extraction helpers. We rebuilt the inputs from pinned public recordings before the complete analysis repeat. Our endpoint compares distinct hippocampal complex source sites at a fixed receiver.
usesUnder independent, exchangeable patient sampling, a 95 percent interval included zero added source shape fit at 100–500 ms in six posterior cingulate SEEG patients sci:sha256:02a9a7c2afdb96c365ea93cee3878ae0b85ab4268d41bcfe7f7416786ec03312
Its conditional shape-fit method informed this analysis. We used a fitted signed scale, fixed bin weights, and a before-pulse comparison. That publication compared hippocampal complex and amygdala responses. The new result compares distinct hippocampal complex sites in the same reused cohort.
usesUnder pulse exchangeability within blocks, testing did not detect late posterior cingulate SEEG response change across ten hippocampal complex pulses in eight patients sci:sha256:17c9b08e401f6301a7d13c7f458da3d25678221ed6c6c87db14e33379c09052c
This upstream publication supplied the pulse-bin method and source extraction procedure used by the input publication. Its pulse-order report informed the fixed train and test groups. The new result uses distinct source sites and a patient-level fit endpoint.
usesdoi:10.18112/openneuro.ds004696.v1.0.1
Source dataset used: OpenNeuro ds004696 version 1.0.1, with its recorded CC0 license.
doi:10.1523/JNEUROSCI.2201-22.2023

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usesSame site templates had lower centered late posterior cingulate SEEG error than other sites in six epilepsy patients with fixed gain and baseline control
We reused metadata selection helpers, pulse bins, and raw retrieval records from this package. Its test fitted voltage scales. It motivated our fixed gain voltage prediction test in the same six patients.