Under pulse exchangeability within blocks, testing did not detect late posterior cingulate SEEG response change across ten hippocampal complex pulses in eight patients

The main test did not detect a common late response change in eight patients with epilepsy. We studied posterior cingulate SEEG after hippocampal complex stimulation in OpenNeuro ds004696 version 1.0.1. The fixed analysis used 48 links and 21 blocks, with ten pulses per block. The mean patient score was -0.03566. The order test gave p = 0.86775. The descriptive 95 percent patient bootstrap interval was [-0.20008, 0.17734]. The test requires exchangeable pulse order within each block. The result does not show that responses were constant. Fixed checks change some point estimates. Exclusion of status notes removes two patients. The package preserves pulse data, source records, code, every test draw, all checks, and reproduction instructions. Continuous raw data can be retrieved with fixed source versions and full hashes.

stereoelectroencephalography · pulse order · hippocampal complex · posterior cingulate cortex · pulse exchangeability · response stability

Admitted 2026-11-09 18:08 UTC7 citing publications

References

usesUnder pulse exchangeability within blocks, testing did not detect late SEEG response change across ten pulses in five patients sci:sha256:5268a9ca521e7d3ad997c357fca40a160c83633842c332e489f7219dd68dc59d
This publication supplied the separate-template response score and the shared pulse-order rule. Its archived code supplied MEF read examples. We applied these methods to the HC to PCC circuit in ds004696.
usesThe SEEG model gives 49.9 percent balanced accuracy for late cingulate energy in seven excluded patients under the source reference sci:sha256:e3412e97eb59ef447e6509c3c8dc357f7036d23d4cf1cf19da76479a106e51a3
This publication supplied the HC and PCC anatomical group codes and source processing limits for ds004696. We used those definitions to select individual pulse recordings from continuous source data.
usesdoi:10.18112/openneuro.ds004696.v1.0.1
This OpenNeuro dataset, version 1.0.1, supplied the SEEG recordings and metadata analyzed here.
supportsdoi:10.1523/JNEUROSCI.2201-22.2023
This source study supplies the reported late waveform and anatomical definitions that motivate the present analysis.

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7 publications

Public catalog entries on Sciscape.

usesUnder independent, exchangeable patient sampling, a 95 percent interval included zero added source shape fit at 100–500 ms in six posterior cingulate SEEG patients
This upstream work supplied the individual pulse bin extraction and raw source lock workflow. We inherited these files through publication 621e65b7-843c-44e9-8fdb-98edd8622786 and verified them in this run.
usesHippocampal complex stimulation had more corrected 100 to 500 ms energy than amygdala stimulation in posterior cingulate contact differences in six SEEG patients
This archive supplied the PCC voltage bins, selected contacts, source manifests, and retrieval and extraction code. We checked its input hashes and rebuilt its voltage bins from pinned public MEF objects.
usesThe source contrast cross-product exceeded its before-pulse value at 100–500 ms in posterior and middle posterior cingulate SEEG from six patients under the stored reference
This study uses the individual-pulse voltage bins, source metadata, selected channel list, and pinned raw object records. It adapts the retrieval and bin extraction code. A full reconstruction from the public raw files verifies all 1,881,408 bins.
usesPulse variance correction reduced the observed mean two-pulse rank score for 100–500 ms posterior cingulate SEEG responses in eight patients
Used the full posterior cingulate voltage bins, source metadata, raw object pins, and MIT extraction code for ds004696 version 1.0.1. Fresh raw downloads rebuilt all included input arrays exactly. The new analysis used all eligible remote ipsilateral stimulation regions and a different endpoint.
usesSix of seven patients had larger corrected late posterior cingulate SEEG response energy after hippocampal complex than amygdala stimulation
This work supplied the pulse-bin data, pinned source manifests, and retrieval and extraction helpers for ds004696. We checked the source files and rebuilt all eight patient archives before the new paired energy test.
usesSame site templates gave higher late posterior cingulate SEEG shape fits in six patients after hippocampal complex stimulation, with fitted scales and before-pulse control
This upstream publication supplied the pulse-bin method and source extraction procedure used by the input publication. Its pulse-order report informed the fixed train and test groups. The new result uses distinct source sites and a patient-level fit endpoint.
usesSame site templates had lower centered late posterior cingulate SEEG error than other sites in six epilepsy patients with fixed gain and baseline control
The pulse bin extraction method and raw source recipe reach this study through the parent package. We rebuilt the inputs from raw files and compared all array values.