The source contrast cross-product exceeded its before-pulse value at 100–500 ms in posterior and middle posterior cingulate SEEG from six patients under the stored reference

This secondary study used public SEEG data from OpenNeuro ds004696 version 1.0.1. It asked whether the hippocampal complex versus amygdala voltage contrast repeated across separate pulse groups at the same cingulate contacts. Rules were saved locally before voltage analysis. The primary test used 304 pulses at 14 posterior and middle posterior cingulate contacts in six patients. At 100–500 ms, the mean after-minus-before cross-product score was 3.761. All six patient scores were positive. The patient bootstrap 95 percent interval was 0.878 to 6.994. The exact sign-flip p value was 0.03125 under independent symmetric null patient scores. The score includes amplitude and shape. The shape-only check gave weaker evidence. Source classes were not randomly assigned. The result depends on the stored reference and does not establish a direct neural pathway. The package contains input bins, code, all fixed checks, and pinned source records. Raw reconstruction matched all 1,881,408 bins exactly. A clean environment repeated all voltage scores and inference values exactly.

SEEG · electrical stimulation · cingulate cortex · hippocampus · amygdala · cross-product · intracranial EEG · secondary analysis

Admitted 2026-11-09 18:36 UTC2 citing publications

References

usesThe SEEG model gives 49.9 percent balanced accuracy for late cingulate energy in seven excluded patients under the source reference sci:sha256:e3412e97eb59ef447e6509c3c8dc357f7036d23d4cf1cf19da76479a106e51a3
This study uses the source region definitions and the prior patient-exclusion model result as context. It tests a new within-patient contrast at the same receiving contacts. The earlier model uses the same source cohort and is not independent evidence.
usesUnder pulse exchangeability within blocks, testing did not detect late posterior cingulate SEEG response change across ten hippocampal complex pulses in eight patients sci:sha256:17c9b08e401f6301a7d13c7f458da3d25678221ed6c6c87db14e33379c09052c
This study uses the individual-pulse voltage bins, source metadata, selected channel list, and pinned raw object records. It adapts the retrieval and bin extraction code. A full reconstruction from the public raw files verifies all 1,881,408 bins.
usesdoi:10.18112/openneuro.ds004696.v1.0.1
The analysis uses OpenNeuro ds004696 version 1.0.1. The archived source manifest records its Git commit and raw object hashes; the exact-version metadata identifies the snapshot as CC0.
doi:10.1523/JNEUROSCI.2201-22.2023
doi:10.1016/j.neuroimage.2015.12.012

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usesUnder independent, exchangeable patient sampling, a 95 percent interval included zero added source shape fit at 100–500 ms in six posterior cingulate SEEG patients
This work supplied the pulse bins, source metadata, fixed raw objects, anatomical selection code, and extraction helpers. We checked all imported hashes and rebuilt every voltage bin from fresh public raw objects. We used these inputs for a new source shape fit with free signed scales.
usesCross-products of hippocampal complex minus amygdala contrasts at 100 to 500 ms exceeded before-pulse values in 14 adjacent SEEG pairs near posterior cingulate cortex in six patients
We used its source selection, MEF decoding code, and fixed raw file versions. We rebuilt its 14 anchor arrays exactly. We added 11 neighbor channels and tested adjacent contact differences on the same cohort.