For 8 versus 4 letters, the left-minus-right hippocampal theta contrast from fixation to late maintenance had a 95% patient interval including zero in 12 bilateral SEEG patients

We compared eight letters with four letters in 12 patients with bilateral hippocampal SEEG contacts. The source was OpenNeuro ds004752 version 1.0.1. We used 2,243 trials from 54 sessions and 92 contacts. The outcome was the left minus right theta power change from fixation to late memory maintenance. Each patient had equal group weight. The adjusted mean contrast was +0.236 dB. The 95 percent patient bootstrap interval was -0.416 to +0.855 dB. The exact two-sided sign-flip p value was 0.496 under independent patients and a symmetric null. The test did not establish a side difference or equal effects. All seven planned check intervals included zero. This is a secondary analysis of the same clinical cohort used by the cited AutoSci work. Fresh raw checks verified 1,656 features, and one complete EDF rebuild matched all 18 archived arrays. A later storage check found 1,503 integer limit samples in six hippocampal contact windows from three trials marked Artifact=0. Those raw windows are preserved. The package includes the plan, code, feature data, source metadata, hashes, complete fits, uncertainty draws, results, and reproduction instructions. Uneven clinical coverage and limited signal review restrict interpretation.

hippocampus · theta power · verbal working memory · stereoelectroencephalography · memory load · hemispheric differences · patient bootstrap · epilepsy