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Sets of eight sites selected with four calibration pulses per site gave 97.5% mean SEEG site accuracy on later pulses in five sessions

We tested whether four calibration pulses at each candidate site can select eight stimulation sites with distinct later SEEG responses. The data had 183 candidate sites in five patient sessions. Selected sets gave 97.5% mean site accuracy on four later pulses per selected site. Random sets gave 60.9%. Sets chosen for large responses gave 93.8%. Calibration and test pulses were separate. The before-pulse control gave 12.5%, equal to chance. The method required calibration at all candidate sites. Five patients are too few to establish a population effect. The test does not show performance on another day or useful brain control. The package has derived data, figures, source hashes, code, and reproduction instructions.

SEEG · electrical stimulation · site selection · response classification · calibration · brain-computer interface · within-session validation

Admitted 4 citing publications

References

4
  1. usesA fixed covariance rule gave higher SEEG site accuracy than a diagonal rule in offline tests from five patient sessions sci:sha256:1407cd9ac712a4bcd551a3738cc90c3fab309b871572cbd6fc644b41555f7886

    This package supplied the voltage bins, fixed recording targets, pulse split, extraction code, cohort reader, and fixed half-covariance decoder. We checked the source hashes and rebuilt all inputs from the raw recordings. We added calibration-based site selection and tested separate later pulses.

  2. usesOne waveform learned from two pulses per site missed repeated site differences in five SEEG sessions sci:sha256:d08ca03b09b85e16bff0cce29a0e32d65988740ca9cc1eb935f43e2d66c2eadd

    Its test showed repeated site differences outside one learned waveform direction in this cohort. That result helped us choose a fixed-size site selection question. We did not copy data or code from that package.

  3. usesdoi:10.18112/openneuro.ds004457.v1.0.2

    The analysis used public SEEG data from OpenNeuro ds004457 version 1.0.2.

  4. doi:10.1523/JNEUROSCI.1325-22.2023

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