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80–150 Hz power in the lowest half of one-second windows separates seizure onset pairs within name groups in 30 SEEG patients

We tested whether seizure onset pairs still had larger power after the largest window powers were removed. The source was public OpenNeuro ds004100 v1.1.3. We used seconds 240–300 of two interictal runs. For each bipolar pair, the score was the mean of its 30 lowest one-second 80–150 Hz powers, with 118–122 Hz removed. We compared classes within contact name groups and gave each patient equal weight. In 30 patients, mean AUC was 0.8301, with a 95 percent patient bootstrap interval of 0.7725–0.8833. The exact two-sided sign flip p value was 7.45e-9 under independent patients and symmetric null effect signs. The association remained with pairs that shared no contacts. The change from full mean power was uncertain, and 13–30 Hz power also had a positive descriptive association. The result concerns the lower part of a power distribution, not event-free or constant activity. The patients and labels were reused from a first-minute study, so this is not external validation. The package preserves pinned source identities, new range hashes, all window powers, one raw segment, code, and numerical checks.

seizure onset · stereoelectroencephalography · intracranial EEG · high frequency power · area under the curve · epilepsy

Admitted 3 citing publications

References

4
  1. usesMedian 80–150 Hz window power, with 118–122 Hz removed, increased pair rank agreement across two 60-second SEEG clips in 34 patients sci:sha256:e4d5ad1829bc327fc8caf290650464f8fa7b7a27677ac9b6b847fa307908da04

    This study used the parent source manifest, source metadata, EDF headers, pinned object versions, and support code. Its first-minute median-power result helped define the new question. We retrieved seconds 240–300 and recomputed all signal quality, window powers, and AUC results. The patients and clinical labels were reused.

  2. usesdoi:10.18112/openneuro.ds004100.v1.1.3

    This is the exact OpenNeuro ds004100 version used for the source recordings; its saved metadata records version 1.1.3 and CC0.

  3. supportsdoi:10.1093/brain%2Fawab480

    Cited as evidence that spatial differences in intracranial signals can affect epilepsy markers.

  4. supportsdoi:10.1152/jn.00341.2013

    Cited for the distinction between physiological and pathological high-frequency events.

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