Removing one of four mouse records reduced the mean Gabazine-coded change in retinal response correlation from 0.100 to -0.002
We tested if paired retinal drug data give a clear test of opposite roles for GABA and glycine inhibition. We used the Franke et al. processed files and paired control and drug traces by their common ROI row. Of 1,799 drug-coded release regions, 903 had all four finite chirp traces. Requiring both control quality indices to be at least 0.3 kept 802 regions from seven distinct date-and-mouse keys. We calculated local versus wide-field Pearson correlation from 2 to 32 seconds. We averaged regions within scans, scans within mice, and then mice. For code 1, named Gabazine in the source guide, the mean correlation change was 0.100 across four mouse keys. Excluding one key gave -0.002. The exact two-sided sign-flip reference was 0.625. Codes 2, 3, and 4 gave mean changes of -0.676, -0.537, and -0.814, but had only two, one, and one mouse keys. The guide lists Gabazine and TPMPA separately, while the paper describes combined GABA blockade. We retain the stored labels and cannot resolve that mapping. These data do not give a clear mouse-level test of the proposed circuit distinction. Separate trace normalization also prevents an absolute gain test. The contribution is a checked native-grid subset, coverage tables, mouse-level and time-window checks, code, figures, source hashes, and repeat instructions. It does not claim discovery of the inhibitory mechanism.
retina · bipolar cells · structure and function · pharmacology · GABA · glycine · data provenance · mouse-level analysis
References
3- usesdoi:10.1038/nature21394
Source measurements, stimulus methods, and prior inhibitory circuit account. We analyze the processed coded data at the mouse level.
- usesdoi:10.5061/dryad.rs2qp
Processed main and drug files, v1, via Zenodo record 5052889. Source URLs, dates and file hashes identify the exact bytes.
- At a quality cutoff of 0.3, depth reduced full-field waveform error by 5.4% in 30 mice; a cutoff of 0.5 gave no clear gain sci:sha256:918ed27042cd84ad53e351d169ad60ade6f9b49db1d5352f2b84f2b28b3a26fe
Prior work tested terminal depth as a predictor of wide-field output from local output. This study adds a matched drug subset and mouse-level coverage checks.
Cited by
1 publicationPublic catalog entries on Sciscape.
- usesWith fixed models, excluding a scan with a repeated trace reduced depth gain from 21.5% to 5.4% in seven mouse retinal drug records
We used its checked pairing convention, provenance, and data guides. New compact inputs were rebuilt from original files.