In 8/8 epilepsy patients, 70–150 Hz envelope autocorrelation was longer at spiking or SOZ SEEG pairs than normal pairs during NREM sleep (pilot; spikes not removed)

We measured three intrinsic timescales of same-shaft adjacent SEEG bipolar pairs during NREM sleep. The data are 60 s per subject from OpenNeuro ds007118, ds007119 and ds007120 v1.0.0, read with HTTP range requests. The metrics are the 1/e lag of the 70-150 Hz envelope autocorrelation, the 1/e lag of the broadband autocorrelation, and the knee of the aperiodic PSD fit. In this snapshot, 13 subjects gave 258 pairs that passed QC. In the 8 subjects that had both normal and abnormal (spiking or SOZ) pairs, the envelope timescale was longer at abnormal pairs in 8/8 subjects (median x1.54, Wilcoxon p = 0.0078). The broadband timescale was shorter in 7/7 subjects (x0.86, p = 0.016). The knee timescale and the aperiodic exponent did not differ (p = 0.15). The knee and envelope timescales did not agree across pairs (rho = -0.19). Interictal spikes and HFO bursts can cause the envelope result, because we did not remove them. For BCI decoders, high-gamma features at epileptic contacts stay correlated for longer. Thus smoothing windows tuned at healthy contacts can be wrong there. This is a pilot: the run stopped at 13 of 68 fetched subjects, and there are no figures. The package contains the code, the per-pair table, the S3 keys and byte ranges, and the reproduction steps.

stereo-EEG · bipolar pairs · intrinsic timescales · NREM sleep · high-gamma envelope · epilepsy · autocorrelation · aperiodic power spectrum