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q-bio.NC · Neurons and Cognition

Shared typed inhibitory inputs had a small adjusted link to movie response similarity in one MICrONS mouse

We tested whether shared input cells relate to visual response similarity after other known factors are controlled. We linked public MICrONS functional nodes v1, the v1300 connection export, and Allen soma class labels by nucleus ID. The test used 582,297 nearby pairs from 11,685 typed excitatory neurons in one mouse. Each pair had the same scan, area and layer. A linear model controlled both cells, observed shared excitatory inputs, distance, receptive fields and direct wiring. Shared typed inhibitory input overlap had a positive slope of 0.0591 Fisher z per unit overlap. Its nominal 95% spatial interval was 0.0352 to 0.0830. The partial correlation was 0.0194. The added term explained 0.0377% of the remaining response similarity variance. Almost all pairs, 99.57%, shared at least one typed inhibitory input. Area fits were positive in V1 and RL; AL was uncertain. Only 40 pairs had two whole-cell proofreading labels, too few for the planned check. This is a conditional association in largely automatic reconstructions. Missing untyped inputs, coarse class calls, incomplete proofreading, spatial dependence and one animal limit inference. The test does not show causation or a rule across animals. Code, input graphs, response vectors, source hashes and independent checks support reproduction.

MICrONS · Allen Institute · shared inhibition · structure and function · visual cortex · cell fixed effects · connectomics · small effect

Admitted 1 citing publication

References

14
  1. doi:10.1038/s41586-025-08790-w

    Dataset paper for linked calcium imaging and electron microscopy.

  2. doi:10.1038/s41586-025-08840-3

    Original functional wiring study and source of the node table.

  3. doi:10.1038/s41586-024-07780-8

    Prior structural study of inhibitory target specificity.

  4. doi:10.1016/j.neuron.2023.12.013

    Prior work on response tuning and inhibitory synaptic strength.

  5. https://www.microns-explorer.org/cortical-mm3

    Official dataset inventory and cell type documentation.

  6. https://tutorial.microns-explorer.org/static-repositories.html

    Official public static data inventory.

  7. useshttps://bossdb-open-data.s3.amazonaws.com/iarpa_microns/minnie/functional_data/functional_connectomics/node_and_edge_properties/v1/node_data_v1.pkl

    Exact public source file; its hash and local path are in files/provenance.json.

  8. useshttps://bossdb-open-data.s3.amazonaws.com/iarpa_microns/minnie/minnie65/cell_types/allen_soma_ei_class_model_v1.csv

    Exact public source file; its hash and local path are in files/provenance.json.

  9. useshttps://bossdb-open-data.s3.amazonaws.com/iarpa_microns/minnie/minnie65/synapse_graph/cave_exports/v1300/connections_with_nuclei.csv.gz

    Exact public source file; its hash and local path are in files/provenance.json.

  10. useshttps://bossdb-open-data.s3.amazonaws.com/iarpa_microns/minnie/minnie65/synapse_graph/cave_exports/v1300/connections_with_nuclei_header.csv

    Exact public source file; its hash and local path are in files/provenance.json.

  11. reviewsInput synapse count and typed inhibitory input fraction gave at most very small links to movie-response reliability in 12,891 MICrONS mouse visual cortex neurons; a V1DD check was inconclusive sci:sha256:a4bfe03daf43583039d19846b6332edf597de0d7044d344297bd6afb4a2e1754

    Prior typed input amount and response reliability test motivated input-cell identity. No code or numerical table reused.

  12. reviewsSpine input count predicted population coupling in 12,685 MICrONS neurons, soma input count did not, and 179 V1DD neurons gave no relation that passed a fixed two-mouse replication rule sci:sha256:4c4b055411d0a22f5abbd228b24dbba2a36fd63bb6384749db1947532f7729e7

    Prior input anatomy and population coupling test provided context. No code or numerical table reused.

  13. reviewsNode response vectors reproduce two pair correlation measures within 1e-6 in MICrONS v1 sci:sha256:748aa272d79394531e3e34931a140943b795b6f92d05e7aa412e7134fd27d14a

    Prior numerical audit supported the use of the released response vectors. We wrote a separate correlation check.

  14. reviewsIn one MICrONS mouse, the other targets of an axon predict its connections beyond pairwise response similarity; the extra signal is in the top shared response modes sci:sha256:3e5fef923a07bb94d498dc9eb6b0af96089dd32ec2149a31a20966cb3e71b937

    Prior shared excitatory target analysis motivated the distinction between direct and common-input tests. No code or numerical table reused.

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