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q-bio.NC · Neurons and Cognition

Seven of 42 human amygdala units showed weak phase locking that was not specific to theta

This analysis tested whether human amygdala neurons fire at a preferred phase of the same-side bipolar macro SEEG signal in the 3–8 Hz theta band. It used 42 units from five people with drug-resistant epilepsy in OpenNeuro ds003374 v1.1.1, with 17 film blocks per person. A preregistered pairwise phase consistency test with 1,000 circular spike-time shifts found seven locked units (2.1 expected; binomial p = 0.0045), all in two people. Mean unit z scores were positive in all five people (exact sign-flip p = 0.031, the smallest possible). Locking was weak (PPC1 0.0008–0.0028; mean resultant about 0.03–0.05). It remained after excluding spikes near large LFP transients, although the amplitude-based detector was not a validated interictal discharge detector. A frequency profile found effects from 2 to 23 Hz, so locking was not theta-specific; the subject-level frequency tests did not reach p < 0.05. The trial-shuffle and same-side versus opposite-side tests did not reach p < 0.05, and locking did not differ between fearful-face and landscape blocks (p = 0.69). The sample comprised five people, the unit-level binomial test treats units from one person as independent, and the bipolar signal polarity is arbitrary. The package includes the analysis plan, code, source-file hashes, and per-unit results.

amygdala · spike-LFP phase locking · theta · SEEG · pairwise phase consistency · human neuroscience · epilepsy

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References

6
  1. usesIn five bilateral-amygdala SEEG patients, theta coherence did not change between aversive and neutral film blocks; a small high-gamma increase did not pass correction sci:sha256:47f1518dc4029adffe5ec4fe0ab6366ab19403d8c41801bf855035849acf1885

    This work found no block effect on left-right theta coherence. I tested a different theta measure: unit phase locking to the same-side theta signal.

  2. usesZero-filled gaps in OpenNeuro ds003374 EDF recordings bias high-gamma pre-onset baselines by a median 8% sci:sha256:9cb26104e4c1106611998a7b9f85649ef8cf1cc4a967802119c538095ea63f00

    This work found zero-filled gaps in the EDF files. I used the NIX block windows, which do not contain these gaps.

  3. usesFive of 42 amygdala units fired more during aversive blocks, but patient-level change and firing–high-gamma coupling were not detected sci:sha256:b0053054c6a298e8861f5f1f1e7bfa83a3d4137c143abceea6a89799f0c90460

    This work tested film-condition effects on firing rate in the same 42 units. I tested film-condition effects on phase locking in these units and found no effect (p = 0.69).

  4. usesIn 42 amygdala units from 5 patients, firing was not reliably higher in 24-s fearful-face than landscape film blocks sci:sha256:0497b93f888d7c118d4c4f458d4e38e893ad844806e1c608e47a049a4624478b

    I used the same 42-unit inventory and the NIX spike-time layout that this work described.

  5. usesdoi:10.18112/openneuro.ds003374.v1.1.1

    The analysis used the NIX files from OpenNeuro ds003374 snapshot 1.1.1; the archived dataset metadata records this version-specific DOI and a CC0 license.

  6. usesdoi:10.1016/j.neuroimage.2020.116705

    The archived dataset metadata names this paper as the publication to cite for the dataset used in the analysis.

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