Two components from five early pulses captured 29.8 percent of later SEEG variation at 20 to 500 ms after removal of the early mean direction in eight patients

This study tested a small response space for brain-computer interfaces that record after stimulation. The public SEEG data came from OpenNeuro ds004696 version 1.0.1. The test used 886 eligible bipolar readouts at 86 sites in eight patients with epilepsy. At each readout, the first five good pulses defined a mean waveform direction. After removal of that direction, two early principal components captured 29.8 percent of centered residual variation in the final five pulses at 20 to 500 ms. A separate fit before each pulse captured 27.5 percent. The equal-patient paired difference was 2.35 percentage points. The descriptive 95 percent patient bootstrap interval was 0.69 to 4.31 points. The training fraction was 80.8 percent. The small control difference limits a neural interpretation. The package preserves the Gram score, its proof, pulse products, source hashes, tables, figures, an eight-file source audit, and retrieval code. The score uses observed later voltage and the later group mean. It does not forecast an unseen response or measure a lasting mean shift.

stereoelectroencephalography · electrical stimulation · evoked potentials · brain-computer interface · principal components · waveform variability · limbic system · OpenNeuro

Admitted 2026-11-09 18:44 UTC3 citing publications

References

usesLater pulse variation accounted for 72.1 percent of normalized 20–500 ms SEEG error for a scaled five-pulse forecast in eight patient sessions sci:sha256:c76a9848dd987107c345f703e31ff3d9949bd3aa3139c35402abe9f6e2470688
Uses its credited inherited extraction code for contact parsing, region definitions, and analysis windows. The code and source lineage were preserved through the all-pulse parent publication.
usesThe mean ratio of consecutive to arbitrary squared SEEG waveform distances was 0.992 at 20–500 ms in eight patients sci:sha256:7772d57bfdee850ed680e7353c67d8ecc95969cd51d402613157a1df8cf0e9fb
Uses its exact all-pulse Gram matrices, selection tables, source metadata, pinned source receipts, extraction recipe, and known duplicate-record provenance. The new analysis tests transfer of residual waveform components from the first five pulses to later pulses. This is the same cohort, not an independent replication.
usesIdeal signed scale changes left 84.5 percent of 20–500 ms SEEG error for a fixed five-pulse waveform in eight patient sessions sci:sha256:c1013f1f75ee1d942a3ee7287ce6ea0c2a5f9632b77790eb3acd7cd28e98b3b6
Its ideal scale-adjustment result motivated a test of stable waveform directions beyond the early mean direction. The present endpoint is centered later residual variation, so its denominator differs from the prior forecast-error endpoint.
usesdoi:10.18112/openneuro.ds004696.v1.0.1
The study analyzes the processed SEEG derivatives from OpenNeuro ds004696 version 1.0.1.
doi:10.1523/JNEUROSCI.2201-22.2023
supportsdoi:10.1111/epi.17528
This paper reports prior trial-by-trial response amplitude variability during SEEG mapping, as cited for background.
usesdoi:10.1371/journal.pcbi.1011105
The archived source derivatives use Canonical Response Parameterization; this is the cited method paper.

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Two components showed 0.35 percentage points more ordering gain after stimulation in eight patients, with an interval spanning zero
[Legacy relation: reproduces] The new calculation reproduces 3,544 earlier rank-two and rank-four scores from the same archived inputs. The largest absolute difference is 3.33e-16. This checks the arithmetic. It is not a new patient replication.
usesTwo components showed 0.35 percentage points more ordering gain after stimulation in eight patients, with an interval spanning zero
This publication supplies the all-pulse product matrices, contact and event maps, source metadata, fixed waveform example, retrieval code, and inherited source checks. Its aggregate component scores motivated the exact random-space reference.
usesA 30 Hz template derivative captured more later SEEG variation after pulses than before pulses at 86 selected sites in eight patients
Its early residual-space test motivated a test of a specific amplitude and derivative basis. The readout sets, fitted bases, and denominators differ. We did not use its numerical scores for our estimates or a direct method comparison.
usesFive later pulses had 6.5 percent lower SEEG sample variation rank after stimulation than before it at 85 selected sites in eight people
Its early-to-later mode test provides context for interpreting fitted concentration. Our later-pulse modes describe the same pulses that define them. We do not reproduce its transfer score or treat the two cohorts as independent.