With site sizes and edge counts fixed, target pair counts for each source forced 2,974 of 3,098 three-target group counts in eight C. elegans brain maps
We tested whether counts for three targets at one chemical synapse site can change when smaller-group counts stay fixed. We used eight C. elegans brain maps from birth to adulthood. For each source neuron, we fixed all source-to-target site counts, all shared target pair counts and the number of sites of each target set size. Exact integer bounds forced 2,974 of 3,098 positive recorded triple counts, or 96.0 percent. The share ranged from 91.9 to 100 percent across maps. Forced keys held 3,293 of 3,432 triple incidences. The main search tested 3,607 possible keys. Of 509 zero recorded keys, 129 could become positive. All intervals had widths of at most three sites. An analysis restricted to sites with exactly three targets forced all 2,051 positive keys. Joining records at a shared source node forced 3,734 of 3,984 positive keys. A target pair count here is specific to one source. It is extra information beyond the ordinary connectome matrix. The result fixes group counts, not site locations. It does not show an absence of biological function or a population age effect. The package supplies code, source hashes, derived tables, exact rational certificates, integer witnesses, figures and repeat instructions. A solver-free checker verified all 10,307 intervals across the three scopes.
connectome · Caenorhabditis elegans · polyadic synapse · target grouping · integer programming · identifiability · exact certificate · hypergraph
References
8- usesdoi:10.1038/s41586-021-03778-8
The source supplies eight chemical synapse site lists and neuron definitions. We use the pinned nature2021 source commit.
- Target pair repeat counts exceeded random means with fixed edge and site counts in eight C. elegans brain maps sci:sha256:fd9de6f2f733031e639058d54b8184abce55a9ab7e3d549d16c86e8a5eb7b254
This study found repeated target pairs after fixed edge and site count controls. We ask how much further information remains in three-target counts.
- Target pair site counts agreed beyond fixed 2 micrometre local counts in two adult C. elegans brain maps sci:sha256:d2d08f36aabe12af4b5fcffb6d3aaa4aaf9460c29a72404d9cf2b6359d03e6a1
This study found cross-animal target pair count agreement after local count controls. Our result concerns exact count freedom after all source target pair counts are fixed.
- doi:10.1038/s42005-021-00637-w
This study gives a prior framework for recovering group interactions from pair observations. Our analysis gives exact feasible count ranges for synaptic groups.
- doi:10.1038/s42005-022-00846-x
The correction is part of the cited hypergraph reconstruction record. We do not use its likelihood or code.
- usesdoi:10.1038/s41592-019-0686-2
SciPy supplies the linear and integer programming interfaces used to find endpoint witnesses.
- usesdoi:10.1007/s12532-017-0130-5
HiGHS supplies the linear programming solver. Exact rational checks verify the numerical solver results.
- doi:10.3389/fncir.2018.00094
The source describes synapse target assignment and uncertainty in C. elegans electron microscopy.
Cited by
2 publicationsPublic catalog entries on Sciscape.
- At an 80th percentile calcium cutoff, local count tests found no clear extra three-cell activity beyond pairwise fits in two adult C. elegans maps
Related count audit showed that source-specific target-pair counts constrain most anatomical triple counts. Those pair counts are not held fixed by our reference.
- usesAt fixed totals and order, pair counts forced 234 to 239 consecutive sets in one mouse table with six axons
We apply its exact constraint approach and rational certificate strategy to an ordered muscle-input score. Our source data, proof and code are independent.