Target pair site counts agreed beyond fixed 2 micrometre local counts in two adult C. elegans brain maps
We tested whether the same target pairs share chemical synapse sites in two adult C. elegans brain maps. Each reference map kept all connection counts, each site's target count, and target counts within 2 micrometre cubes fixed. We subtracted each map's reference mean from each pair count. The adult residual vectors had a cosine of 0.567. Their agreement score was 655.37, compared with a joint reference 95 percent range of -30.03 to 29.13. No draw reached the recorded score in 2,000 draws for each of three related conditional tests. Removing RIAL and RIAR as sources reduced the cosine to 0.352. Shifted grids, merged shared nodes and longer runs kept agreement. Secondary birth comparisons and later smaller-cube checks were also positive. The result shows repeated anatomical grouping beyond the tested local counts. Fine contact geometry and annotation choices remain possible causes. The data do not show synapse survival or common neural activity. The package preserves code, source hashes, full sampled counts, figures and repeat instructions.
connectome · Caenorhabditis elegans · polyadic synapse · target grouping · fixed margin model · spatial controls · reproducible analysis
References
7- usesTarget pair repeat counts exceeded random means with fixed edge and site counts in eight C. elegans brain maps sci:sha256:fd9de6f2f733031e639058d54b8184abce55a9ab7e3d549d16c86e8a5eb7b254
We use its site selection, Curveball trade code and source hashes. We extend its within-map repetition test to cross-animal agreement after local count adjustment. It also supplied the prior RIA examples.
- usesdoi:10.1038/s41586-021-03778-8
The source study supplies the synapse records, neuron identities and geometry for Dataset1, Dataset7 and Dataset8.
- doi:10.1186/s12915-026-02539-1
This study reports conserved spatial synapse clusters and RIA enrichment. Our test measures two targets at one site under fixed local count constraints.
- usesdoi:10.1038/ncomms5114
Curveball trades sample binary site-target matrices with fixed row and column totals.
- usesdoi:10.1103/PhysRevE.91.042812
The convergence result motivates the trade rules, including failed trades.
- usesdoi:10.1103/PhysRevE.94.039902
This erratum is part of the cited Curveball method record.
- supportsdoi:10.3389/fncir.2018.00094
The source describes proximity-based assignment and uncertainty in potential postsynaptic targets in worm electron microscopy.
Cited by
3 publicationsPublic catalog entries on Sciscape.
- usesWith local counts fixed, shared synapse sites had higher adjusted calcium coactivity scores in two adult C. elegans maps
We reuse its MIT C++ fixed-margin site sampler, without code changes, to produce target-pair counts.
- With site sizes and edge counts fixed, target pair counts for each source forced 2,974 of 3,098 three-target group counts in eight C. elegans brain maps
This study found cross-animal target pair count agreement after local count controls. Our result concerns exact count freedom after all source target pair counts are fixed.
- Co-target count deviations at gap links were within target contact reference ranges in JSH and N2U nerve-ring maps
It tests shared chemical target sites beyond local counts. We test their overlap with electrical links in different source maps.