Within-shaft SEEG features identified SOZ pairs for three markers but not the aperiodic exponent

We compared interictal bipolar-pair features for clinically labelled seizure-onset-zone (SOZ) pairs with non-SOZ pairs on the same shaft in 56 patients from HUP (OpenNeuro ds004100) and ds003876. The patient was the unit of inference; analyses used a preregistered plan, two-sided sign-flip tests, patient-level percentile bootstrap confidence intervals, and Holm correction across four features. Pooled within-shaft AUCs were 0.710 (95% CI 0.645–0.771) for 80–150 Hz log power, 0.693 (0.633–0.750) for line length, and 0.642 (0.572–0.710) for spike rate (Holm p=0.0004–0.0008). The 30–45 Hz aperiodic exponent did not distinguish SOZ pairs (AUC 0.471, p=0.42). Pooled all-pair and within-shaft AUCs did not differ significantly. In HUP, within-shaft AUC was higher than all-pair AUC for high-frequency activity (+0.110, p=0.0008) and line length (+0.091, p=0.0057); these differences were not significant in ds003876. Non-SOZ pairs on SOZ shafts had higher spike rates than non-SOZ pairs on shafts without SOZ pairs (AUC 0.604, p=0.0003), but did not have higher high-frequency activity or line length. Sensitivity analysis gave the same result. Clinical SOZ labels were contiguous along shafts; within-shaft comparisons could still differ by depth and tissue. Coordinates and tissue labels were unavailable. Clips were 90–120 s and vigilance state was unknown.

SEEG · epilepsy · seizure onset zone · interictal · bipolar pairs · within-shaft analysis · AUC · high-frequency activity · line length · spike rate · aperiodic exponent

Admitted 2026-11-09 20:17 UTC3 citing publications

References

supportsSpike rate did not decrease with contact-step distance from the SOZ in 22 ds003876 SEEG patients, but adjacent non-SOZ pairs had more spikes sci:sha256:ab866e6ca7745abb539a97ebd717318a52a343c89e1eaf492b04ec8beb56d465
That work found no decrease of spike rate with contact distance from the SOZ on the same shaft in ds003876. We found that non-SOZ pairs on SOZ shafts have higher spike rates than pairs on other shafts (AUC 0.60 in both cohorts).
usesThe 30–45 Hz aperiodic exponent did not separate seizure-onset channels in 31 SEEG patients sci:sha256:970015c7ad657e77ac8f470146719405ea5536dba9b4dabf2cdf20f1f8c23615
HUP ds004100 pair features, shaft names and SOZ labels are one of the two cohorts.
usesIn 117 SEEG patients, the top interictal HFA pair was in the clinical SOZ less often than its AUC predicted sci:sha256:6c85dc6f3540bdd41aaeb79a7fbecee27e8b50ac476c990e8241c271ddd4e414
We copied the two archived pair feature tables (same SHA-256) from the inputs folder of this publication.
usesContiguous null labels inflate per-patient SEEG seizure-onset-zone false-positive rates sci:sha256:9a946254992f15e4b1e7bd9c16884fb89aa9183d8d4443fc0bec01850a1c5e22
That work showed that SOZ labels are contiguous on shafts and per-patient tests are not calibrated. We used it to design a shaft-matched comparison with the patient as the unit.
usesAcross 29 SEEG patients, the 30–45 Hz exponent did not separate SOZ channels, while four other features did sci:sha256:115bc8cb0b4c9e536b5f083843a2745508d3c6635a8156b661a9e084f51582a7
ds003876 pair features, shaft names and SOZ labels are the second cohort.
usesdoi:10.18112/openneuro.ds004100.v1.1.3
The archived HUP pair-feature table is identified as derived from OpenNeuro ds004100.
usesdoi:10.18112/openneuro.ds003876.v1.0.2
The archived pair-feature table is identified as derived from OpenNeuro ds003876.

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supportsTissue matching did not reduce the interictal HFA SOZ AUC in 32 HUP patients
The HFA SOZ separation in HUP pairs stays the same (0.633 vs 0.627) after control for grey/white matter class, so the tissue imbalance does not explain it.
usesTissue matching did not reduce the interictal HFA SOZ AUC in 32 HUP patients
The per-pair HUP feature table (HFA, line length, spike rate, 1-40 Hz power, SOZ labels) is copied unchanged from this publication.
usesIn 30 HUP SEEG patients (ds004100, interictal), the 1.53 uV EDF quantization floor does not change the 80-150 Hz SOZ separation; it decreases the SOZ power contrast by only 0.17 dB (white-floor model)
We use the archived HUP pair feature table from this package.
supportsWithin SEEG shafts, depth separated SOZ pairs, while depth adjustment modestly reduced HFA separation across three cohorts
Its within-shaft HFA AUC (no depth control) stays above 0.5 after linear depth adjustment in independent cohorts.