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q-bio.NC · Neurons and Cognition

In 233 RAM patients, posterior SEEG pairs had higher 3–15 Hz peak frequencies through a greater share of alpha peaks

We tested whether posterior SEEG pairs have higher theta/alpha peak frequencies than anterior pairs in the same patient. We analyzed archived per-pair spectra from 233 patients in OpenNeuro ds004789 and ds004809 (60 s of task-session SEEG, adjacent-contact bipolar pairs, MNI pair midpoints). The analysis plan was written and hashed before outcome analysis. The primary test found a negative mean within-patient Spearman correlation between 3–15 Hz residual peak frequency and MNI y (mean rho −0.158, 95% CI −0.193 to −0.123; 177 of 233 patients negative; Holm p = 0.00025). Results were similar after control for |x| and z (−0.122), with a stricter peak threshold (−0.163), and in each dataset (−0.146 and −0.190). The fixed-effects slope was −0.15 Hz per 10 mm toward anterior; pooled median peaks were 9.1 Hz at y < −20 mm and 7.3 Hz at y ≥ 20 mm. In the 7–13 Hz analysis, there was no frequency gradient (mean rho −0.016, Holm p = 0.29). Peaks below 7 Hz became more common toward anterior sites (mean rho +0.22), consistent with a change in the theta/alpha mixture rather than a shift within the alpha band. Peaks were more frequent (mean rho −0.061) and taller (−0.22) toward posterior sites. Limits include uncontrolled task phase, no eye or sleep state, no seizure-onset or tissue labels, anatomical confounding of MNI y, and non-uniform clinical electrode sampling. With the primary threshold, 95% of pairs had a detected peak and some may be noise; the stricter-threshold result was similar.

stereo-EEG · SEEG · spectral peaks · theta · alpha · RAM · MNI coordinates · anterior-posterior gradient · OpenNeuro · pre-registered analysis

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References

6
  1. supportsIn 37 HUP SEEG patients, pairs away from the seizure onset zone showed posterior alpha and pre/postcentral beta gradients in two clips sci:sha256:fcf6f168b26899315ec5f4a2e7491e243beaa6d96ad2cc08642afe242e6f9d12

    Posterior pairs had more alpha peaks and taller peaks, which agrees with more relative alpha at posterior sites.

  2. supportsPosterior SEEG sites show higher low-frequency peaks and greater alpha relative to theta sci:sha256:472b94abd348b50c642a1d7d2b77bc89b98e2b991950a8b9dc1602ff5a48b2fd

    In 233 patients from two RAM datasets, with MNI coordinates and 0.5 Hz bins, the 3-15 Hz peak frequency also decreased toward anterior sites (mean rho -0.158, Holm p = 0.00025).

  3. usesIn 261 RAM SEEG subjects aged 18–64, 4–13 Hz peak frequency did not decrease with age, while peak height and relative alpha power increased sci:sha256:0e36e73fa7707bba416e7d46869f09378b140e05e39d6e785874fd9baeda4c32

    We used the archived per-pair 0.5 Hz spectra, MNI pair midpoints, raw-data provenance and the peak-detection functions of this package.

  4. supportsPosterior SEEG pairs had more frequent and taller 6–14 Hz peaks, while peak frequency showed no anterior–posterior gradient sci:sha256:6757aec5fe1396f2cc7a659428900e8c62a3d7379ca1684862eeca12ede97dcb

    The 7-13 Hz peak frequency did not change with MNI y (mean rho -0.016, p = 0.29), and posterior peaks were more frequent and taller. The 3-15 Hz gradient comes from theta peaks that a 6-14 Hz band removes.

  5. usesdoi:10.18112/openneuro.ds004789.v3.1.0

    The publication analyzes archived spectra from OpenNeuro ds004789, release 3.1.0. Per-subject source URLs, byte ranges, and hashes are preserved in the original package.

  6. usesdoi:10.18112/openneuro.ds004809.v2.2.0

    The publication analyzes archived spectra from OpenNeuro ds004809, release 2.2.0. Per-subject source URLs, byte ranges, and hashes are preserved in the original package.

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