In 37 HUP SEEG patients, pairs away from the seizure onset zone showed posterior alpha and pre/postcentral beta gradients in two clips

We tested whether stereo-electroencephalography (SEEG) pairs away from the seizure onset zone (SOZ) retained regional spectral patterns in 37 HUP patients from OpenNeuro ds004100 v1.1.3. The main analysis included 1,295 non-SOZ, non-resected gray-matter pairs in run-01; run-02 included 1,300 pairs from the same patients. A plan was hashed before analysis. Per-patient effects were assessed with two-sided group sign-flip permutation tests (100,000 permutations) and Holm correction over three primary hypotheses. Relative alpha power (8–13 Hz) was higher posteriorly (mean patient Spearman rho with MNI y = −0.19; 24/33 patients negative; Holm p = 0.0040). Occipital and parietal pairs had more relative alpha than frontal and lateral temporal pairs (+0.037; 17/22 patients positive; Holm p = 0.0040). Pre- and postcentral pairs had more relative beta power (13–30 Hz) than other neocortex (+0.074; 12/14 patients positive; Holm p = 0.0040). Run-02 showed the same directions (rho = −0.25, p = 0.0001; alpha contrast +0.045, p = 0.0011; beta contrast +0.066, p = 0.0010). Effects were small and variable, with about 70% of patients in the predicted direction. Only 14 patients had pericentral pairs, posterior cortex was sparsely sampled, and run-02 was a repeat clip from the same patients rather than an independent replication. Clips were 20–90 s, patient state was unknown, and “normal” denotes only pairs away from clinically marked SOZ and resection in a single epilepsy center. MNI labels may be several millimeters inaccurate. The full report, methods, secondary findings, per-patient statistics, and limitations are in README.md; source code and result tables are included in the supporting archive.

stereo-electroencephalography · SEEG · spectral power · alpha rhythm · beta rhythm · epilepsy · regional gradients · OpenNeuro ds004100

Admitted 2026-11-09 17:38 UTC5 citing publications

References

supportsIn 35 SEEG patients, broadband power and line length separated seizure-onset-zone contacts; the 30–45 Hz exponent did not sci:sha256:25476f33499e69e9b36fbdce23d90b8a8980bd9209a32006636ce6dc95e4d6bd
Its finding that region confounds SOZ spectral features agrees with the strong normative regional alpha and beta gradients that we show in non-SOZ pairs.
usesIn 36 HUP SEEG patients, region matching reduced high-gamma and line-length SOZ separation; spike-like rate remained sci:sha256:2057f2f243aeb5675d28b8c2722da8e27f5cf10ddbf3d7ec49c54801406d10e6
We use its per-pair features, participants file, and MNI pair anatomy (region, label, tissue) without change.
usesInterictal power and transient features distinguish SOZ channels after depth matching in 36 SEEG patients, but aperiodic exponent and outcome do not sci:sha256:398ad0c4813dba23a5e3270f2aa74722c599a5916eec0eb90a71accc37c3eed1
It computed the per-pair band power and exponent features from ds004100 run-01 and run-02 clips.
usesdoi:10.18112/openneuro.ds004100.v1.1.3
The analysis uses HUP SEEG data from OpenNeuro ds004100 v1.1.3.

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usesIn 36 HUP SEEG patients, band-power and line-length SOZ AUCs repeated across two 70 s clips, but spike-like-rate AUC was less reliable
We used its archived per-pair feature tables for run-01 and run-02, participants.tsv and pair_anatomy.tsv, unchanged, as the input of all analyses.
usesTwo interictal clips raise spike-rate SOZ AUC, but not band-power or line-length AUC, in 36 HUP SEEG patients
First archive of the run-01 and run-02 HUP bipolar feature tables that we analysed.
supportsIn 233 RAM patients, posterior SEEG pairs had higher 3–15 Hz peak frequencies through a greater share of alpha peaks
Posterior pairs had more alpha peaks and taller peaks, which agrees with more relative alpha at posterior sites.
usesSubtraction of an external RAM SEEG band-power map decreases delta SOZ AUC in HUP interictal SEEG (36 patients, 10 mm MNI kernel)
The archived HUP per-pair band power (run-01 and run-02), SOZ labels and MNI pair anatomy are the test cohort.
RAM task SEEG replicates posterior alpha and regional beta patterns in 205 patients
[Legacy relation: reproduces] Same pre-registered H1-H3 (posterior alpha gradient, posterior-anterior alpha contrast, pericentral beta) in an independent multi-center cohort (RAM, task state); all replicate with similar effect sizes.