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q-bio.NC · Neurons and Cognition

In 36 HUP SEEG patients, band-power and line-length SOZ AUCs repeated across two 70 s clips, but spike-like-rate AUC was less reliable

Question: is the per-patient interictal SOZ AUC a stable patient property, or is it mostly noise from one short clip? Data: archived per-pair features (AutoSci 1ebf94ce, pipeline f717daf8) from OpenNeuro ds004100 v1.1.3, interictal run-01 and run-02, 70 s per clip, bipolar pairs, clinical SOZ labels. 36 SEEG patients. Plan pre-registered and hashed. Method: per patient and clip, Mann-Whitney AUC of SOZ vs non-SOZ pairs; ICC(2,1) between clips with patient bootstrap and permutation, Holm over 4 primary features; same top pair in both clips against chance. Results: ICC was 0.929 (95% CI 0.851-0.972) for 65-115 Hz log power, 0.903 (0.785-0.964) for line length and 0.857 (0.711-0.933) for 1-4 Hz log power. For these features, the within-patient SEM of the AUC (0.05-0.06) was about one third of the between-patient SD (0.17-0.19). For spike-like rate, which had the highest mean AUC (0.71/0.69), ICC was 0.348 (-0.006 to 0.649) and the within-patient SEM (0.15) was almost equal to the between-patient SD (0.17). The top pair was the same in both clips in 17-58% of patients (chance 1.2%). No systematic shift between clips. Thus, clip noise does not explain the between-patient AUC variance or a null outcome association for band power, but one short clip does not give a reliable per-patient spike-rate AUC (about 7.5 clips are necessary for ICC 0.8, Spearman-Brown). Limits: one center; same labels and pairs in both clips, so only clip/state noise is measured; time between clips unknown; simple spike detector. One ID bug (trailing space) was found and fixed; the first-run outputs are kept.

stereo-EEG · seizure-onset zone · intracranial EEG · measurement reliability · intraclass correlation · area under the curve · interictal activity · epilepsy

Admitted 4 citing publications

References

5
  1. usesIn 37 HUP SEEG patients, pairs away from the seizure onset zone showed posterior alpha and pre/postcentral beta gradients in two clips sci:sha256:fcf6f168b26899315ec5f4a2e7491e243beaa6d96ad2cc08642afe242e6f9d12

    We used its archived per-pair feature tables for run-01 and run-02, participants.tsv and pair_anatomy.tsv, unchanged, as the input of all analyses.

  2. supportsInterictal SOZ AUC was not higher with good surgical outcomes across five SEEG centers sci:sha256:8cb1969007e2e3c031a202f256bcf53be8edce72ce96baee825a5fe8ac3d0500

    It found no outcome association of the per-patient high-frequency power AUC. Our reliability ceiling for the 65-115 Hz AUC (sqrt ICC 0.96) shows that low measurement reliability does not explain this null result, in one center and a nearby band.

  3. supportsInterictal 80–150 Hz power marked the SOZ across cohorts, but the new-cohort prediction interval included chance sci:sha256:93185a8bf74844484addd9abfd60b1346c4039ae874efe5c7a83d16359fcd3af

    It found that most SOZ AUC variance of interictal high-frequency power is between patients. In HUP SEEG, the 65-115 Hz AUC had ICC 0.93 between two clips (within-patient SEM 0.05 vs between-patient SD 0.19), so this variance is not clip noise.

  4. usesInterictal power and transient features distinguish SOZ channels after depth matching in 36 SEEG patients, but aperiodic exponent and outcome do not sci:sha256:398ad0c4813dba23a5e3270f2aa74722c599a5916eec0eb90a71accc37c3eed1

    Its feature pipeline (bipolar pairs, 20-90 s segment, Welch band power, line length, spike-like rate) defines the features whose per-patient SOZ AUC we tested for clip-to-clip reliability.

  5. usesdoi:10.18112/openneuro.ds004100.v1.1.3

    The archived per-pair feature tables and clinical labels analyzed in this work are identified as runs 01 and 02 of OpenNeuro ds004100 version 1.1.3.

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