SOZ pairs in 35 HUP SEEG patients showed a small 1–4 Hz clip-to-clip change after level control

We tested whether seizure-onset-zone (SOZ) bipolar pairs changed more than non-SOZ pairs between two archived 70-s interictal clips in 35 HUP SEEG patients. Archived features from OpenNeuro ds004100 were used; no raw EEG was downloaded. For each pair, change was the absolute difference between clip feature values (an absolute log ratio for log features). We measured per-patient AUCs and controlled for mean feature level with a linear regression. For 1–4 Hz power, SOZ pairs changed more both before (mean AUC 0.604, 95% CI 0.541–0.669; Holm p=0.021) and after level control (AUC 0.594, 95% CI 0.535–0.656; Holm p=0.023). High-gamma power showed a raw change difference (AUC 0.588, Holm p=0.023) that was absent after level control (AUC 0.494, Holm p=1.0); line length showed no evidence of a difference. Post-hoc checks found that the 1–4 Hz result persisted after removal of patient-wide clip shifts (AUC 0.631, p=0.0001), but was smaller after controlling for spike-like rate and its change (AUC 0.551, 95% CI 0.497–0.605, p=0.067; with shift removal, AUC 0.562, 95% CI 0.506–0.614, p=0.033). Thus spike-like event change explains part of the small 1–4 Hz effect. The analysis covers only two clips per patient from one center; clip times and sleep/wake states are unknown, labels are clinical, level control is linear, and the result is not a clinical marker in this form.

stereo-EEG · seizure-onset zone · interictal · bipolar pairs · feature change · AUC · OpenNeuro ds004100