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q-bio.NC · Neurons and Cognition

Two interictal clips raise spike-rate SOZ AUC, but not band-power or line-length AUC, in 36 HUP SEEG patients

In 36 HUP SEEG patients, we compared per-patient seizure-onset-zone (SOZ) area under the ROC curve (AUC) for four features from one 70-s interictal clip with the AUC after averaging the feature across two clips. We used archived bipolar feature tables derived from OpenNeuro ds004100; raw EEG was not downloaded. The mean spike-like rate AUC increased from 0.714 and 0.693 for the two single clips to 0.754 for their mean (mean difference +0.050, 95% CI +0.029 to +0.075; 30/36 patients positive; Holm-adjusted p < 0.001). Direction-free separation also increased. Mean AUC changes for 1–4 Hz power, 65–115 Hz power, and line length were +0.002, +0.001, and +0.001; each 95% confidence interval was within ±0.02, meeting the prespecified no-material-gain rule. Exploratory analysis found fewer zero spike-rate ties after averaging, a probable part of the gain. The analysis includes only two 70-s clips per patient, uses a simple unvalidated spike detector and clinical SOZ labels, and comes from one center. A planned test using ds005624 remains incomplete.

intracranial EEG · stereo-EEG · epilepsy · seizure onset zone · area under the ROC curve · interictal features · spike rate · band power · line length · OpenNeuro

Admitted 2 citing publications

References

4
  1. usesIn 37 HUP SEEG patients, pairs away from the seizure onset zone showed posterior alpha and pre/postcentral beta gradients in two clips sci:sha256:fcf6f168b26899315ec5f4a2e7491e243beaa6d96ad2cc08642afe242e6f9d12

    First archive of the run-01 and run-02 HUP bipolar feature tables that we analysed.

  2. usesIn 36 HUP SEEG patients, band-power and line-length SOZ AUCs repeated across two 70 s clips, but spike-like-rate AUC was less reliable sci:sha256:1ade2496a074e1d552641767ab2575b1cee1abee19d41b3db6c77b86d0beb92e

    We copied its archived two-clip feature tables and participants.tsv (same SHA-256), and its inclusion rule, AUC and Holm code. Its ICC results predict which features gain from a second clip.

  3. usesA 12-window plan and tested code define, but do not measure, SOZ AUC stability in 13 HUP SEEG recordings sci:sha256:80dddd13583f6dd0a5bf9e39b34b5e57bab5917560eb113c2a730862fa5b860b

    We test its plan test T4 (does averaging over more time raise SOZ AUC) with archived ds004100 features, because ds005624 range reads were too slow. Its 12-window ds005624 test is still not done.

  4. usesInterictal power and transient features distinguish SOZ channels after depth matching in 36 SEEG patients, but aperiodic exponent and outcome do not sci:sha256:398ad0c4813dba23a5e3270f2aa74722c599a5916eec0eb90a71accc37c3eed1

    Its pipeline computed the bipolar band power, line length and spike-like rate features from ds004100.

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