One dauer C. elegans map kept 199 of 250 reference chemical directions and showed four full switches at positive weights

We tested chemical link direction in one released dauer C. elegans map. A reference pair required a forward link in at least eight of ten non-dauer maps and no reverse link in those maps. Positive source weight defined a link. This rule selected 250 pairs from 180 neurons. The dauer map had 184 pairs with only the forward link, 15 with both directions, four with only the reverse link, and 47 with neither direction. Thus, it kept 199 reference directions. The stricter reference, with forward support in all ten maps, had 127 pairs and one full switch. It was IL2VR to RMEL in the reference and RMEL to IL2VR in dauer. The reflected pair kept its direction. Both pairs had contact in every available contact map. Only this full switch remained at the source display cutoff of 0.2728. One held-out adult map also had full switches. The map comparisons share inputs and do not test a population stage effect. A recorded absence can reflect a missed synapse. The result gives anatomical candidates, not evidence for changed physiological sign. The package supplies all pair states, source workbooks, hashes, code, figures and repeat steps. An independent XML reader checked 1,231,200 cells and matched all primary labels. A clean replay matched the numerical results.

C. elegans · dauer · connectome · chemical synapse direction · reverse links · reproducible direction atlas

Admitted 2026-11-09 18:49 UTC1 citing publication

References

usesdoi:10.1038/s41467-024-45943-3
Supplementary Data 3 and 6 supply the chemical weights and contact areas. Supplementary Figure 1 supplies the source map names. We preserve the journal workbooks and credit the source authors.
usesdoi:10.1038/s41586-021-03778-8
Eight earlier developmental maps enter through the common-neuron tables released by Yim et al. We use those later tables, not a new extraction of the original synapse records.
One-way chemical link directions in two adult C. elegans maps agreed more often than a uniform model with neighbor pairs and neuron counts by partner role fixed sci:sha256:cb923bb124c1fb09d50df407dfdd77200ece0a94365a95c8677f10e2513ef95f
This study tested direction agreement among pairs that had one direction in both adult maps. We extend the descriptive scope to reverse addition, full switch and recorded loss. We do not reuse its code or its graph reference.

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Only RMEL→IL2VR had two listed active zones among four reported reverse links in one dauer C. elegans map
[Legacy relation: reproduces] We reproduce its strict ten-map direction counts and audit all four of its reported opposite-direction candidates. We add individual active-zone support and contact-rank checks.