One-way chemical link directions in two adult C. elegans maps agreed more often than a uniform model with neighbor pairs and neuron counts by partner role fixed
We tested whether one-way chemical link directions agree between two adult C. elegans brain maps beyond exact neuron counts. The main set had 162 neurons and 725 pairs that were one-way in both maps. There were 699 matching directions. A uniform reference kept each map's neighbor pairs and each neuron's input and output counts by partner role fixed. Exact component enumeration gave a mean of 681.77 matches and a central 95 percent range of 674 to 689. The exact upper-tail graph fraction was about 0.00000334. The rules fixed 651 pair directions in both maps, including 637 matches. Among the remaining 74 pairs, there were 62 matches against an exact mean of 44.77. Partner role counts reduced the excess over a neuron-count reference by about 73 percent. Removal of L/R partner edges and inclusion of all 180 source neurons kept a residual. At cutoffs of three or five records, each role graph had only one feasible orientation. These controls could not test direction agreement. Three other disjoint map pairs show the scope. The result is conditional on uniform orientations and the stated counts. It does not estimate a population effect or identify a biological wiring mechanism. The package has code, compact input facts, source hashes, exact states, full distributions, graph draws, figures, audits, and repeat instructions.
connectome · Caenorhabditis elegans · chemical synapse · direction conservation · graph orientation · conditional graph model · exact enumeration · neuron role · reproducible research
References
5- usesdoi:10.1038/s41586-021-03778-8
Source chemical synapse records, neuron labels, roles, integration labels, and age metadata at Git commit 0646af9d25896ae660f97d462eab2d67282f5625.
- doi:10.1371/journal.pcbi.1007526
Prior use of neuron roles in the architecture of the worm network.
- doi:10.1111/ejn.14988
Prior analysis of one-way and reciprocal chemical connections. Our outcome is direction agreement between animals.
- Contact area controls reduced excess two-way chemical links relative to fixed-degree models of 162 neurons in seven C. elegans brain maps sci:sha256:cb6521f9a7ca217bc005add76a9ca7d31d146de09e7d928cda907d4b662a6988
Prior study of graph control sensitivity for chemical reciprocity. We test a different outcome with neighbor pairs fixed.
- usesTrial, wiring and distance count rules forced 88 of 94 two-way detections in a C. elegans atlas of 111 neurons sci:sha256:e550465a5343e8a899b16e4c5c2eeb6ccf04eb79eb661a91c24aa179b11a7b90
We use the idea of reporting forced entries with a conditional reference. The present graphs are chemical orientations in individual animals. We wrote new code and added exact two-graph block distributions.
Cited by
3 publicationsPublic catalog entries on Sciscape.
- Only RMEL→IL2VR had two listed active zones among four reported reverse links in one dauer C. elegans map
Prior work tested direction agreement for pairs that were one-way in two adult maps. We include all four dauer direction states.
- One dauer C. elegans map kept 199 of 250 reference chemical directions and showed four full switches at positive weights
This study tested direction agreement among pairs that had one direction in both adult maps. We extend the descriptive scope to reverse addition, full switch and recorded loss. We do not reuse its code or its graph reference.
- supportsAt fixed neuron totals, early directions cut adult count deviance by 2.4–4.6% in two C. elegans maps with matched contact smoothing
Our early-to-adult count scores give related evidence for direction information beyond specified neuron totals. This is a different conditional test from its adult one-way orientation reference.