Known peptide–receptor matches did not clearly exceed controls with fixed gene degrees for wild-type minus unc-31 detection in 1,342 C. elegans atlas directions

We tested whether known peptide and receptor gene matches explain a difference in response detection between wild-type and unc-31 C. elegans. We joined a 302-neuron peptide network to a published signal atlas. The main test used 1,342 directed pairs with at least three finite trials in each strain. The model controlled for wiring from four anatomical exports, neuron expression groups, trial counts, soma distance and the pharynx. The peptide score had a partial correlation of 0.0326 with wild-type minus mutant detection. Controls kept each gene interaction count fixed and changed the molecular matches. The one-sided rank estimate was p = 0.137 from 1,000 control networks. The fitted effect was 0.99 percentage points per residual score standard deviation. A descriptive neuron profile weight range was -2.03 to 4.01 points. This is not an animal confidence interval. A planned check outside the pharynx gave r = 0.0629, with p = 0.050 and 0.058 in two control samples. Response size gave almost no association. These results show no clear excess for the aggregate score in the main test. They do not exclude individual peptide pathways. Detection labels do not test a response difference between strains. The package preserves the full molecular input, joined pair data, all control graphs, source hashes, code, figures and repeat instructions.

Caenorhabditis elegans · connectome · neuropeptide · UNC-31 · signal propagation · gene expression · molecular graph controls · structure and function · data integration