Mean locality rose under propofol after site adjustment in 20 EEG and 23 fMRI adults; the iEEG test did not confirm it

We tested whether measured coupling becomes more local under propofol after additive site terms are removed. Separate public studies supplied human 10 Hz iEEG, scalp EEG and BOLD fMRI. Locality is a partial rank correlation of pair strength with proximity. Development used four patients and 26 MRI adults. A local code lock preceded tests in seven other patients and 23 adults from a separate MRI study. Mean changes were +0.06779 [-0.03033, +0.16590] and +0.04810 [+0.02523, +0.07098]. Brackets give pointwise 95% person Student intervals. The first shared test failed, raw p=0.078125. We then fixed an extension before scoring EEG from 20 independent adults. The EEG change was +0.02011 [+0.00321, +0.03701]. The EEG/MRI shared test passed, with p=0.022160 after correction for both shared claims. The original failed claim remains. The extension reuses the same MRI adults; it does not confirm the iEEG claim. Imaginary-coherency intervals included zero in both electrical studies. All negative people and controls remain. A fixed latent-field model changed the score when only independent readout noise changed. Thus site adjustment does not identify a neural communication range. Separate cohorts, source filters, clinical sampling, sensor mixtures and unequal drug states limit scope. Code, permitted compact data, source terms, plans, all scores, figures and repeat steps are supplied.

propofol · intracranial EEG · scalp EEG · fMRI · spatial coupling · partial rank correlation · independent people · negative result