Control for direct awake links lowered profile alignment with propofol coupling in seven iEEG patients and 23 fMRI adults

We tested whether similar awake coupling profiles align with coupling during a source propofol condition. We controlled each pair's own awake link, site terms and selected spatial terms. Separate public human studies supplied 10 Hz iEEG cross-spectra and BOLD fMRI correlations. Development used four patients and 26 MRI adults. A local code lock preceded tests in seven other patients and 23 adults from another MRI site. The original shared residual test failed. Mean scores were 0.03890 and 0.00117. Their 95% person Student intervals were [0.01999, 0.05781] and [-0.00292, 0.00526]. A second test came from development. It asked if direct awake-link terms lower the profile relation. Mean reductions were 0.01847 and 0.04604, with intervals [0.00584, 0.03110] and [0.03559, 0.05649]. This shared test passed after Holm correction for two claims (p=0.015625). Both tests used people as units. Each required Student and sign-flip evidence in each measurement. All negative scores, fixed controls and undefined cases remain. An independent method checked 120 scores. A fixed common-source model and a measurement-error identity set interpretation limits. The result concerns associations in processed measurements. It does not show direct neural routes, retained awareness or a cause. Clinical samples, separate cohorts, unequal sensing, source processing and absent repeat windows limit the scope. The package gives code, exact permitted inputs, source versions and terms, plans, all outcomes, figures and repeat instructions.

propofol · intracranial EEG · fMRI · common neighbors · functional connectivity · measurement error · reproducibility