A fixed distance test did not confirm a shared propofol effect in seven iEEG patients and 23 fMRI adults
We tested whether the propofol condition gives a stronger preference for coupling between nearby brain sites. Separate public studies supplied human intracranial EEG at 10 Hz and slow BOLD fMRI. Development used four patients and 26 MRI adults. A local plan and code lock preceded tests in seven other patients and 23 adults from a separate MRI study. The person score was awake minus anesthesia rank correlation of distance with squared normalized coupling. Mean scores were +0.07127 and +0.02600. Their 95% person t intervals were [-0.05327, +0.19580] and [-0.00034, +0.05234]. Positive counts were 4/7 and 15/23. The fixed shared test required positive mean and majority evidence in each measurement. It failed, p=0.50. Depth-only and gray-cortex electrical means were near zero, with wide intervals. MRI sign treatment and implant coverage gave different descriptive scores. These controls cannot replace the failed shared test. Small clinical samples, source filters, cohort differences, motion, vascular effects, reference mixtures and absent window-level data limit the result. It does not establish no effect or a causal role for consciousness. The package gives exact compact public inputs, source versions and terms, plans, code, all person results, figures and repeat instructions.
propofol · intracranial EEG · fMRI · spatial coupling · cross-modal test · negative result · reproducible data
References
7- usesRemoving one shaft from the average reference replaced a mean 11.3% of top 10% beta debiased squared wPLI links and 8.7% of coherence links in 60 second samples from 34 SEEG patients sci:sha256:3aaae744ee89fb567851107dd55cf25f71b997838481f87ba35fe6920b6ef451
Its reference sensitivity result informed the different-array and imaginary-coherency controls. We do not reuse its signals or code.
- usesdoi:10.5281/zenodo.7657814
Version-specific public electrical cross-spectra, labels and coordinates, reused under CC BY 4.0.
- usesdoi:10.1073/pnas.2207831120
Source electrical study and preprocessing methods.
- usesdoi:10.5281/zenodo.6955280
Version 1 public MRI Dataset1 and Dataset2 correlation matrices, reused under CC BY 4.0.
- usesdoi:10.1038/s41467-022-35764-7
Source MRI cohort descriptions, processing and matrix order.
- usesdoi:10.1093/cercor/bhx179
Schaefer400 parcel order and coordinates support distance and coverage controls.
- doi:10.1097/ALN.0000000000005479
Prior human iEEG results show why a uniform loss of coupling is not assumed.
Cited by
3 publicationsPublic catalog entries on Sciscape.
- usesControl for direct awake links lowered profile alignment with propofol coupling in seven iEEG patients and 23 fMRI adults
We reuse public source-fetch and lossless-compaction code through the later verified package.
- Mean locality rose under propofol after site adjustment in 20 EEG and 23 fMRI adults; the iEEG test did not confirm it
[Legacy relation: reproduces] Our unadjusted distance controls reproduce its reported mean scores. We add the site-adjusted endpoint and a separately fixed scalp-EEG extension. This prior test was found during a broader catalog check after our original endpoint scores.
- usesAfter site and distance bin control, weak coupling rank alignment remained across propofol in seven iEEG patients and 23 fMRI adults
We reuse its verified lossless compact source inputs, atlas pin, public source-fetch and compaction code. We test a new fixed spatial persistence prediction.