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Acoustic models predicted response differences within omitted sound categories in one iEEG panel and eight fMRI adults

We tested whether acoustic features predict response differences within a sound category that was absent from fitting. Separate public human studies supplied one selected iEEG panel and fMRI from eight adults. All fits used 165 common sounds and 12 source labels. A fixed ridge model used six spectrum and 63 modulation features. Each fold excluded a whole category. Evaluation removed category means. BOLD fits used scans 1 and 2; test responses came from scan 3. Mean within-category correlation was 0.285121 in 32 distinct electrical profiles and 0.228828 across BOLD people. The 95% BOLD person t interval was 0.208762 to 0.248894. Both refitted sound-label tests gave Monte Carlo p=0.001; all eight BOLD people were positive. The fixed conjunction p was 0.00390625. Secondary refit sound bootstrap ranges were 0.208 to 0.347 and 0.182 to 0.251 with people fixed. BOLD site scores and one category-person score were negative. All results remain. Missing electrical patient labels limit that evidence to the fixed panel. This is a new endpoint in reused data, not new-cohort confirmation. The result supports acoustic prediction across the supplied labels in these selected measurements. It does not show a common neural code or causality. Clinical sampling, source selection, shared stimuli, broad labels and measurement differences limit scope. The package gives code, source versions and terms, plans, uncertainty checks, all derived scores, figures and repeat instructions. Original arrays remain external.

auditory cortex · intracranial EEG · fMRI · natural sounds · category generalization · encoding models · cross validation

Admitted 5 citing publications

References

6
  1. usesCombined sound features gave positive mean gains over both single sets in 11 iEEG patients and eight fMRI adults sci:sha256:d3f382a918d33ee6d84d34c4e83b6ac1b02dc9350f35af96200eb63c734ddb9a

    This auditory model benchmark motivated the distinction between mixed-category prediction and omitted-category within-category prediction.

  2. usesA test that removed 69 acoustic features did not confirm sound agreement in one iEEG panel and eight fMRI adults sci:sha256:2d4c61b53d6c8d4ee01056958f3b4bd9ebd6c48f301dcbc1b62e826006a9443b

    We reuse its original-source manifest and duplicate-profile audit. We respect its fixed-panel electrical scope and test a different endpoint.

  3. usesdoi:10.1016/j.neuron.2015.11.035

    Source of the human fMRI response matrix.

  4. usesdoi:10.1016/j.cub.2022.01.069

    Source of the electrical response examples and acoustic features.

  5. doi:10.1371/journal.pcbi.1003412
  6. doi:10.1371/journal.pbio.3003293

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