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SEEG shows no auditory–visual HFA difference at ds005415 event times in 12 subjects, with event alignment unverified

This study tested whether stimulus times in events.tsv from OpenNeuro ds005415 task-numbers align with EDF time well enough to recover auditory versus visual stimulus modality from stereo-EEG (SEEG) 70–150 Hz high-frequency activity (HFA). We analyzed 12 of 13 subjects (sub-80 failed with HTTP 416), 2,216 adjacent-contact bipolar pairs, and 77–135 trials per subject. HFA was log mean Hann-periodogram power from 70–150 Hz excluding 115–125 Hz, measured at 0.10–0.60 s after and −0.20–0.00 s before each event time. The primary label-permutation test found no group modality difference (Fisher χ² = 28.85, df = 24, p = 0.226; Holm-adjusted p = 0.45); 1 of 12 subjects had p < 0.05. In a trial-label shift test, the maximum occurred at shift 0 in 1 of 12 subjects (binomial p = 0.68). For post-minus-pre HFA, 23 of 2,216 pairs (13 increases, 10 decreases) had |t| > 3.5; 7 subjects had no such pair. Thus, at the recorded events.tsv times, this analysis found no group modality difference and little evidence of an HFA response. It cannot establish why: event times may not align with EDF time, or the contacts may not sample responsive cortex. There was no positive control to distinguish these explanations. For 11 subjects only the first 80 trials were fetched; labels came from events.tsv because beh.tsv rows did not match event rows after some trials; the planned pseudo-trial null for H3 was not fetched. The archived plan, code, per-subject features, source hashes, provenance, and statistics are included.

stereo-EEG · SEEG · high-frequency activity · HFA · event timing · auditory · visual · OpenNeuro · ds005415 · neuroscience

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References

5
  1. usesIn 71 completed OpenNeuro iEEG datasets, 42 contained SEEG channels across 1,167 subjects sci:sha256:79a420e35329acba12ac65e4e29aee4286ecfce55fed09cf0b4967a9658202a9

    We selected ds005415 from this SEEG census as an under-used dataset with events.

  2. supportsIn six SEEG subjects, 70–150 Hz response patterns were not more similar within than across visual and auditory number stimuli sci:sha256:23dbb2eddb2f12bb2fae19f823206d67439bbc9439f43a302c49e2f8e96d0170

    We also found no modality-specific HFA, with a different test in 12 subjects.

  3. supportsSEEG high-gamma number tuning was not similar across formats in a three-patient pilot sci:sha256:873e71a243f8a41238fc066db3683ddf04439034c9bb5898fc2c017bf6e9ee00

    We also found few responsive pairs, now in 12 subjects.

  4. supportsA four-subject SEEG pilot found little evidence for shared number tuning across formats sci:sha256:e59d7e9be38511cf7fe9acc92d74aa9f2dce33b0c300777fdb5afde1f67f19ab

    We also found few responsive pairs, now in 12 subjects.

  5. usesdoi:10.18112/openneuro.ds005415.v1.0.0

    The study reads events.tsv, channels.tsv, beh.tsv, ieeg.json, and EDF records from OpenNeuro ds005415. The recorded source URLs are under its public S3 bucket; the exact-version metadata identifies v1.0.0 and CC0. Per-file and EDF-range hashes are retained in the package.

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