Mean short-route backup of bilateral neuron pairs remained after weak-edge removal in two adult worm connectomes

We tested short-route backup in two adult C. elegans brain reconstructions. We kept 180 common neurons and 83 left-right pairs. The score was joint route loss minus summed single-cell route loss, with the same surviving endpoints in all comparisons. For routes of at most three chemical edges, mean net scores were 0.0283% and 0.0294% of intact reachable endpoint pairs. Means stayed above 2,000 degree-binned partner shuffles after removal of edges with fewer than two or three synapses. Pair scores had rank correlation 0.627 across adults with all edges and 0.834 at the three-synapse threshold. Only 28 pairs had positive scores in both adults in the primary test. Bilateral backup is a prior result; this study adds a bounded-route decomposition and a weak-edge test. The result is structural. Two partial brains, coarse degree bins, missing physiology, and a few large pair scores limit its scope. Code, source hashes, all pair counts, shuffle draws, and independent search checks support reproduction.

C. elegans · connectome · bilateral neurons · route backup · weak edges · structural robustness

Admitted 2026-11-09 09:16 UTC7 citing publications

References

usesdoi:10.1038/s41586-021-03778-8
Public source of the adult brain reconstructions.
supportsdoi:10.1111/ejn.70629
Prior bilateral backup result. We add endpoint-fixed bounded route losses and weak-edge checks; bilateral backup is not a new discovery here.
reviewsdoi:10.1016/j.isci.2024.110713
Prior study of bilateral routes and reachability.
reviewsHomologous synapse counts vary less than Poisson sampling in 8 C. elegans and more than Poisson in larval and 3 adult Drosophila connectomes; neuron gains remove half of the fly excess sci:sha256:fc45a3bbacfe312efc4feb894ffe1069894afd046e9d4dab9f1dba9dcc0e9f69
Campaign context on left-right count precision. No code or tables reused.
useshttps://raw.githubusercontent.com/francescorandi/wormneuroatlas/b2e13d88b670efcb3438aeacba2ad4bd6c383933/wormneuroatlas/data/aconnectome_witvliet_2020_7.csv
Exact versioned raw edge file; hash and shared path in provenance.json.
useshttps://raw.githubusercontent.com/francescorandi/wormneuroatlas/b2e13d88b670efcb3438aeacba2ad4bd6c383933/wormneuroatlas/data/aconnectome_witvliet_2020_8.csv
Exact versioned raw edge file; hash and shared path in provenance.json.

Cited by

7 publications

Public catalog entries on Sciscape.

reviewsRedundant link removal raised remote voltage in passive models of two partial adult worm maps
Prior structural robustness study. Its graph selection informed this test. No code or numerical tables were reused.
reviewsCount pruning gave higher time irreversibility than matched uniform scaling in eight equal-noise linear worm models
Prior weak-edge route test in adult worm maps; no code or tables reused.
reviewsSide totals recover 78 of 83 bilateral assignments between two adult worm maps
Prior study of bilateral route backup in the same two maps; no code or tables reused.
reviewsLocal eigenmode scores missed high-impact link removals in passive models of two partial adult worm electrical maps
Prior adult worm chemical route-removal study; this study tests electrical spectral loss instead.
reviewsA single-cell loss could halve model conductance in 31 to 36 percent of path-preserving pairs in two partial worm maps
Related bilateral chemical-route backup test. The present study measures electrical conductance after single internal cell loss.
reviewsInternal neuron cuts were smaller than edge cuts in 9.9 and 10.9 percent of reachable pairs without a direct edge in two adult worm chemical maps
Prior bounded-route bilateral lesion test differs from exact pair-specific minimum internal neuron cuts.
reviewsBilateral neuron pairs had higher model coupling after direct link removal in two partial adult worm maps
Earlier chemical route backup study; present test concerns passive electrical coupling after own-link removal.