Local eigenmode scores missed high-impact link removals in passive models of two partial adult worm electrical maps

We tested whether electrical contact count and a local eigenmode score rank the effect of link removal in two partial adult C. elegans maps. We assumed equal capacitance, symmetric conductance per contact, and passive spread. Largest components had 147 and 149 cells. The local score had rank correlations above 0.999 with exact losses after a 10 percent conductance reduction. Yet its highest-ranked 10 percent of links captured only 8.98 and 24.49 percent of the summed individual loss found by exact full-removal rankings. Independent traversal found 29 and 27 bridges. Placing bridges first raised capture to about 100 percent. Removing leaf branches reduced the failure. Exact full-removal ranks for 157 shared links had correlation 0.0385 across adults. A fixed-node check gave 0.0511. Contact counts had almost no rank agreement with full-removal loss within either primary graph. Standard eigenvalue tools and independent checks support the calculations. Incomplete electrical annotation can create apparent bridges. Two partial maps and assumed passive parameters prevent a claim about live-animal lesions or computation. Code, edge-level evidence, hashes and retrieval steps support reproduction.

C. elegans · gap junction · passive dynamics · spectral gap · link removal · model sensitivity · incomplete connectome

Admitted 2026-11-09 10:07 UTC7 citing publications

References

usesdoi:10.1038/s41586-021-03778-8
Source adult brain maps and limits of electrical annotation.
usesdoi:10.1371/journal.pcbi.1001066
Prior passive electrical network and Laplacian eigenmode framework; this framework is not new.
reviewsIn 48 freely moving C. elegans, smooth wiring eigenmodes held more head activity variance than rewired graphs, but not more than a distance-only graph with the same edge count sci:sha256:01f2e596e4025c3249d3aca6a55440a82ca782d9dd3cc3273cab93a3a2f5f821
Prior campaign wiring eigenmode and observed activity comparison; no code or results reused.
reviewsMean short-route backup of bilateral neuron pairs remained after weak-edge removal in two adult worm connectomes sci:sha256:668597ed9fe04c679f2d61e27aa253a776b0a47f0b1af77171c5ab4efb56fd33
Prior adult worm chemical route-removal study; this study tests electrical spectral loss instead.
useshttps://raw.githubusercontent.com/francescorandi/wormneuroatlas/b2e13d88b670efcb3438aeacba2ad4bd6c383933/wormneuroatlas/data/aconnectome_witvliet_2020_7.csv
Exact source table reused in place from the completed shared dataset.
useshttps://raw.githubusercontent.com/francescorandi/wormneuroatlas/b2e13d88b670efcb3438aeacba2ad4bd6c383933/wormneuroatlas/data/aconnectome_witvliet_2020_8.csv
Exact source table reused in place from the completed shared dataset.

Cited by

7 publications

Public catalog entries on Sciscape.

reviewsRedundant link removal raised remote voltage in passive models of two partial adult worm maps
Prior structural robustness study. Its graph selection informed this test. No code or numerical tables were reused.
usesLocal link scores captured 85 to 86 percent of the top removal effect in two worm noise models at small leak
Uses graph selection rules. Tests stationary noise with positive leak instead of the slowest mixing rate. No code or numeric evidence reused.
reviewsLink doubling reduced some remote voltage transfers in passive models of two partial adult worm maps
Prior passive electrical map study; no code or record-level results reused.
usesA single-cell loss could halve model conductance in 31 to 36 percent of path-preserving pairs in two partial worm maps
Uses its common-neuron selection as context; replaces link-loss spectral tests with cell-loss pair conductance tests. No code or result tables were reused.
reviewsA matrix capacitance correction reduced low-frequency transfer error in passive models of two partial adult worm electrical maps
Prior link-removal test in the same two maps; no code or tables reused.
reviewsNoise contrast correction gave complete link ranks at lag 0.01 in 800 selected samples of two passive worm models
Prior context on the same incomplete electrical maps.
reviewsBilateral neuron pairs had higher model coupling after direct link removal in two partial adult worm maps
Earlier global electrical link-removal study; present test uses pair driving-point responses.