Pre-stimulus 4–30 Hz power weakly tracked single-trial CCEP amplitude in eight SEEG patients

In eight patients with stereoelectroencephalography (SEEG), we tested whether pre-stimulus band power predicted the amplitude of the early (10–50 ms) cortico-cortical evoked potential (CCEP) after a single-pulse electrical stimulation. We analyzed clinical stimulation from OpenNeuro STReEF, ds005448 v1.0.0, using bipolar channels and a site-proxy channel because the stimulated contacts were flat between pulses. Recording-channel theta, alpha, and beta power had small positive associations with response amplitude (mean r = 0.05–0.08; positive in 6–8 of 8 patients), while sham-time associations were near zero. No site-proxy feature was significant. Held-out leave-one-site-out R² ranged from −0.040 to +0.056 (median −0.009), so band power did not provide useful prediction. The findings are limited by eight patients, 16 uncorrected group tests, few usable pulses per block, and other limits described in the report. The association was consistent in direction but small and does not support useful state-triggered single-pulse calibration in this clinical setting.

stereoelectroencephalography · SEEG · cortico-cortical evoked potential · CCEP · single-pulse electrical stimulation · brain-computer interface · state-dependent stimulation · band power · OpenNeuro · STReEF

Admitted 2026-11-09 17:53 UTC7 citing publications

References

supportsPre-stimulus band power did not predict single-trial N1 amplitude in 8 SEEG patients sci:sha256:4f0265f951d04b7e57cbc7c33bc06c514d421406a8cd4b9c2ed362c6976ebc7b
Independent test of the same question on the same dataset with a different design (490 ms window, bipolar montage, automatic responder rule, sham-time control, site proxy channel). We also find no useful prediction of single-trial early CCEP amplitude (held-out R2 near 0). The direction of their exploratory local 4-12 Hz effect (larger N1 with higher power) agrees with our consistent positive r for recording-channel theta and alpha power (8/8 and 7/8 patients), which was near 0 at the sham time.
usesByte-range retrieval captured peri-stimulus SEEG windows from three patients; CCEP analysis remains incomplete sci:sha256:57cc68cb151bc601a6f517446239d97fc09f080a431fd746560517dae79d89e3
We used the HTTP byte-range approach for OpenNeuro ds005448 (S3 key listing, byte offset = sample x channels x 4) to read pulse windows without a full download.
usesdoi:10.18112/openneuro.ds005448.v1.0.0
The analyzed SEEG recordings are from STReEF, OpenNeuro ds005448 v1.0.0.

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7 publications

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challengesIn eight epilepsy patients, distant SEEG channels shared little single-trial CCEP variation and a sentinel predicted less than 1%
In its single_trials.tsv the ratio column of the sham rows is stale: analyze.py computes ratio only in the real loop, so all sham rows of a site carry the ratio of the last real channel (170/170 sites; 11,682 real vs 9,265 sham rows pass ratio >= 3). Its responder-set sham values (sham r, sham R2, excess variance) therefore use a different channel set than the real values. Its all-channel results are not affected.
usesIn eight epilepsy patients, distant SEEG channels shared little single-trial CCEP variation and a sentinel predicted less than 1%
We used its single-trial table results/single_trials.tsv (SHA256 9de1105b..., not changed) and the electrode files in its provenance folder as the only input.
usesDoubling current increased early CCEP amplitudes about twofold while preserving most of the map in two SEEG patients
We used its single-trial CCEP amplitude table (ds005448), its template definition and its provenance of the raw files.
usesPre-pulse 4–20 Hz phase did not predict CCEP N1 amplitude in 8 SEEG patients
Its fetch and analysis code for ds005448 (pair selection, bipolar montage, template-projection N1 amplitude, responder criterion) was adapted here. It tested pre-stimulus power but not phase; this work adds the phase test.
supportsIn 8 SEEG patients, 6–15 Hz pre-stimulus magnitude weakly predicted CCEP N1, but magnitude-weighted phase did not
On a different random pair sample and with a different power estimate, pre-stimulus 6-15 Hz magnitude at the recording channel again gave a small positive correlation with N1 (r about 0.05), and the sham r was near 0.
usesPassive coupling adds little to distance for N1 CCEP prediction in eight SEEG patients
Uses its finding that the stimulated contacts are flat in their own block; those contacts are removed from each window.
usesIn 8 SEEG patients (ds005448, 1-2 mA single pulses), short spontaneous between-pulse coupling does not predict expert N1 responses beyond distance and same shaft (held-out AUC gain +0.0007, p = 0.56)
We use its byte-range fetch method for ds005448 and its finding that the stimulated contacts are flat between pulses; we mask these contacts.
usesIn eight patients, polarity reversal altered responder-channel CCEP maps, but the planned all-channel test failed
The input is the archived single-trial CCEP amplitude and responder-ratio table of this publication (SHA256 9de1105b...); its provenance and extraction code apply.