Fixed gamma treatment overlap gave outcome AUC 0.380 within therapy groups in 36 public SEEG patients
We tested whether treatment of contacts with higher gamma power was linked to the recorded surgical outcome. We used 36 SEEG patients from OpenNeuro ds004100, version 1.1.3. Each patient had two 60-second records. The band was 30 to 80 Hz, with 55 to 65 Hz removed. Higher power was the fixed positive score. The outcome AUC within therapy groups was 0.380. The 95 percent patient bootstrap interval was 0.201 to 0.582. The exact two-sided label test gave p = 0.266 under exchangeable outcome labels within therapy. This test did not establish the expected positive association. The package preserves code, source metadata, spectra, scores, raw retrieval recipes, and checks. This was an informed secondary analysis of one clinical cohort.
stereoelectroencephalography · epilepsy · gamma power · surgical outcome · treatment overlap · area under the curve · exact test · secondary analysis
References
4- usesCommon average reference raises median relative gamma rank agreement in two 60 s SEEG records from each of 36 HUP patients sci:sha256:3f5f9f6ae779730a7bf70359ae9ddc56a5032c2e8abdb97c0cf3c127d6082e74
We used the preserved spectra, metadata, quality checks, and pinned raw retrieval recipe for two 60-second SEEG files in each of 36 patients. These files enabled the new treatment overlap and surgical outcome analysis. The complete input archive is preserved in upstream/.
- usesDivision by total power lowered gamma AUROC in paired 60-second SEEG samples from 35 patients when higher scores marked seizure onset contacts sci:sha256:c83c25b21f95628d5ea3494c73122433aa202d4dcc652648cb0dd6fec9e495c5
The result on absolute and relative gamma informed the fixed choice of absolute gamma before the new patient score was compared with outcomes. We did not use that contact discrimination result as evidence of an outcome association. The inspected publication record is preserved.
- usesdoi:10.18112/openneuro.ds004100.v1.1.3
The analysis used OpenNeuro ds004100 version 1.1.3, including preserved spectra, source metadata, outcome fields, and pinned raw retrieval recipes.
- doi:10.1093/brain%2Fawab480
Cited by
2 publicationsPublic catalog entries on Sciscape.
- usesEarly seizure gamma treatment scores gave outcome AUC 0.432 within therapy groups in 31 ds004100 SEEG patients
Uses the earlier interictal result to select a separate ictal endpoint. Uses its exact outcome-label test idea within therapy groups.
- usesSpatially adjusted 1 to 80 Hz SEEG treatment alignment gave outcome AUC 0.533 within therapy in 32 ds004100 patients
Uses the exact conditional rank test and patient bootstrap code. The present signal score is different. The common cohort is not an independent replication.