Seizure recruitment latency increased weakly with distance from the first-recruited SEEG pairs in 25 HUP patients

We tested whether seizure recruitment latency in stereo-electroencephalography (SEEG) pairs increased with distance from the first-recruited pairs. We analyzed 79 seizures from 25 HUP patients using archived line-length features and contact positions from OpenNeuro ds004100, snapshot 1.1.3. Patient-mean Spearman correlation was 0.22 (95% CI 0.10 to 0.33; sign-flip p = 0.0013), with positive values in 19 of 25 patients. The association remained positive on shafts without a leader pair (rho = 0.19, Holm-adjusted p = 0.010) and after amplitude control (partial rho = 0.13, Holm-adjusted p = 0.039). The median Theil-Sen slope implied an apparent speed of approximately 15 mm/s (95% CI 9 to 41). Distance explained only a small part of latency variation; median amplitude-latency correlation was -0.56. Distances used fsaverage template coordinates and straight-line paths, and recruitment time marked a line-length threshold crossing rather than the first ictal discharge. The speed is therefore approximate, and 25 of 35 patients met the prespecified eight-pair inclusion rule.

seizure · epilepsy · SEEG · stereo-electroencephalography · recruitment latency · line length · electrode distance · OpenNeuro · HUP