In 24 HUP SEEG patients, clinical SOZ pairs start line-length seizure activity earlier but do not stop it later than other involved pairs

We compared seizure activity start and end times in clinical seizure-onset-zone (SOZ) and other involved bipolar pairs in 24 HUP SEEG patients and 81 seizures, using archived 1–45 Hz line-length features and a previously archived detector. The patient-mean end-time AUC was 0.559 (95% CI 0.466–0.649; p = 0.23), with no evidence that SOZ pairs stopped later. The confidence interval rules out a patient-mean end-time AUC above 0.65 for this detector and analysis. SOZ pairs started earlier (AUC 0.310; Holm-adjusted p = 0.0014; median shift −5.7 s). End-time AUC after adjustment for start time was 0.477 (Holm p = 1.0). Involvement-duration AUC was 0.643 (Holm p = 0.0056), reflecting earlier starts; adjustment for involvement strength gave end-time AUC 0.511 (Holm p = 1.0). End-time AUC remained 0.51–0.56 with p > 0.2 across sensitivity analyses. The result applies to a z-threshold line-length end marker and clinical SOZ labels. Labels were not blinded to onset, spatial distance was not controlled, and only seizures with both SOZ and non-SOZ involved pairs were included.

stereo-EEG · epilepsy · seizure-onset zone · ictal activity · line length · termination time · area under the curve · HUP dataset