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Fixed report readers failed a shared pain reversal ranking test in 114 EEG adults and 20 fMRI adults

We tested whether neural weights fitted to pain reports at fixed heat improve trial ranking when lower heat has the higher report. Separate public studies supplied scalp EEG and BOLD fMRI. Development used 39 EEG adults and eight MRI adults. A local code lock preceded new reversal scores in 114 other EEG adults and 20 other MRI adults. Mean report-minus-heat fitting gains were 0.27 points, with 95% person Student limits -0.81 to +1.35, and 5.70 points, with limits +0.68 to +10.72. Report-reader accuracies were 45.18% and 56.78%. The shared rule required above-chance report ranking and positive gain in both modalities. It failed. A second shared rule that bounded gain below five points also failed. Both two-claim Holm values were 1.0. An added sparse MRI study retained 87 adults. Its gain was 4.74 points but accuracy was 49.50%, with limits 46.52% to 52.47%. Its full transport rule failed. Refitting readers in whole-person resamples put both MRI gain ranges across zero. All negative people and fixed controls remain. A Gaussian selection example gave 40.41% reversal accuracy despite within-input correlation 0.5. Independent loops rebuilt all 221 scored person results exactly. Fresh source checks matched all EEG features and hashes, MRI metadata and selected MRI values. The package supplies a checked challenge, permitted compact inputs, code, models, all results, source pins, figures and repeat steps. No common gain or gain bound was confirmed. Source selection, small MRI training sets, cohort differences, sparse support and measurement filters limit scope. No pain-specific or causal process was established.

human neuroscience · pain reports · EEG · fMRI · trial ranking · cross-modal tests · negative results · reader uncertainty

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References

13
  1. usesWith fixed readers, mean heat contrast kept more than half its early size in 115 EEG and 19 fMRI adults; the joint drift test failed sci:sha256:83f4b8f393394c05739e3dfe843029e9c6d13f7759ba9de97c178328cf4a9635

    Supplied verified compact inputs, heat-reader preparation and public-source audit code. We test a new report reversal endpoint.

  2. usesFixed neural readers tracked pain reports across heat levels in 117 EEG and 20 fMRI adults; another MRI test failed sci:sha256:7b1b8681ddb2e1ae572776b38a8856e466efaefc0710c889e3e3f98a89f4edf9

    Supplied verified sparse MRI inputs, geometry mapping and source records. Its across-heat report transfer result motivates this distinct inversion challenge.

  3. supportsNeural scores trained on heat level tracked adjusted pain reports in 115 EEG adults and 20 fMRI adults sci:sha256:23f65a3fa079f4037761d6eb145841339f455f2c424de8f10fe006c3c9f00216

    Prior adjusted report coupling and trial-change results motivate the difference between within-input association and inversion ranking.

  4. usesWith fixed models, past reports reduced pain report error in 115 EEG adults and 20 fMRI adults; a shared neural gain was not confirmed sci:sha256:ea23a2dfa07130d856665342291585a790d53bf46a201ac9e90e6a1a8fbcf4a8

    Original full BMRK4 grid extraction and provenance supplied through the verified immediate packages.

  5. usesExploratory record checks in 114 EEG and 87 fMRI adults gave positive heat rank covariance; three primary shared tests failed sci:sha256:06bd2f1b523bdd21df2962abacc6c3fe4ffc905f1461ccd82080508b56a69848

    Original geometry-only BMRK5 sparse extraction supplied through the verified immediate package.

  6. doi:10.1371/journal.pbio.3003948
  7. usesdoi:10.17605/OSF.IO/BS3YJ

    Version-1 public EEG event-feature tables; all six source file hashes were checked.

  8. usesdoi:10.6084/m9.figshare.12795116.v1

    BMRK4 version-1 public trial maps and reports.

  9. doi:10.7554/eLife.15166
  10. usesdoi:10.6084/m9.figshare.19491326.v1

    BMRK5 version-1 public trial maps and reports, reused as sparse derivatives.

  11. doi:10.1038/s41562-020-0819-8
  12. doi:10.1371/journal.pbio.3001620
  13. doi:10.1056/NEJMoa1204471

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