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Four calibration pulses per site selected eight sites with higher mean later-pulse identification accuracy than random sets in five SEEG sessions

We tested selection of eight stimulation sites from one bipolar SEEG response pair. We used all five patients and 185 eligible sites from OpenNeuro ds004457 version 1.0.2. Four early pulses per candidate site set templates and selection scores. The final four pulses formed the test. The fixed response window was 30 to 100 ms after the pulse. Mean later-pulse accuracy was 63.1% for selected sites and 36.6% for 2000 random sets per patient. The mean gain was 26.5 percentage points. The descriptive 95% patient bootstrap interval was 13.0 to 41.2 points. The exact two-sided patient sign-flip p value was 0.0625. Selection by voltage size reached 65.0%, so the new selection rule did not show an advantage over that method. A control selected from signals before the pulse reached 15.0%; chance was 12.5%. The package preserves signal bins, source metadata, models, selected sets, predictions, random subsets, three figures, code, hashes, and retrieval instructions. The result applies to later pulses within the same session and stimulation blocks. It does not establish neural origin, useful perception, or performance on another day.

stereoelectroencephalography · electrical stimulation · site identification · calibration · human neuroscience

Admitted 3 citing publications

References

4
  1. usesFour pulses gave better mean response ranks than one pulse in five offline bipolar SEEG tests sci:sha256:c9015b4b89ceffc195f0e36e740e7eae7d03e41d8ed41a831cef61e3e6bd2754

    Its four-calibration-pulse and four-later-test-pulse design informed the fixed budget. No signal arrays or analysis code were imported from this publication. The patient sample is shared.

  2. usesSEEG response shapes at 15–100 ms gave higher site identification accuracy than shapes at 100–500 ms within each of five patient sessions sci:sha256:aa5b71d76d214f861e99964287f9da01f3f9fc6c707a4dcfe24807283918ab40

    Its archived 5 ms signal bins, eligible event rows, source metadata, raw-file manifest, and raw retrieval and extraction code enabled this new small-site-set test.

  3. usesdoi:10.18112/openneuro.ds004457.v1.0.2

    Source signal bins and metadata are from OpenNeuro ds004457 version 1.0.2.

  4. doi:10.1523/JNEUROSCI.1325-22.2023

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