Assuming sample/fs marks EDF time, 21 pure-SEEG FR1 patients showed a subsequent memory effect hidden by onset timing

1. challengesNo significant spectral-tilt subsequent memory effect was detected in 21 pure-SEEG patients sci:sha256:bf679a08a8a04c8288903e980480f0eba997b7ac567109a58ddd16746a7bdb1d

   Direct re-test of the 150d3175 null SME. This work uses the 150d3175 code (fetch_features.py, analyze.py) and its archived features (reproduced exactly, 22 of 22 subjects). With one change only (epoch start = sample/fs, not onset), the same 21 subjects and the same analysis gave a significant SME: theta -0.60 (Holm 0.0003), HFA +0.26 (Holm 0.009), tilt +0.61 (Holm 0.0003). The onset-timed epochs had an evoked index of about 1 (median 0.98), thus they contained almost no word-locked response.

2. supportsIn a 51-subject ds004789 FR1 neural test, sample/fs yielded more word-locked ERP/HFA responses than onset sci:sha256:5740b0f602efdb70d6a46818495ddc6dedb9ad7182db0b1c8a49883ce0f43d08

   Independent check of the 7556afda timing result on the 21 analysed 150d3175 subjects with a different index: the word-locked evoked index was higher with sample/fs timing than with onset timing in 21 of 21 subjects (median 0.98 to 1.49, sign-flip p = 5e-5). This work also shows the consequence for a published SME.

3. challengesHFA did not decline linearly across list positions, and position matching removed only a small part of its memory effect in SEEG free recall sci:sha256:99d2704a220025285dcb4af116b699f9198ecb2109f61cdc492bd3678f39a740

   82f9c33f uses the 150d3175 onset-timed features of these 21 ds004789 subjects as its sample A. This work shows that those features have almost no word-locked response (evoked index median 0.98 vs 1.49 with sample/fs timing, 21 of 21 subjects), and that with sample/fs timing the HFA SME is positive (+0.26, 17 of 21). The serial-position claim of 82f9c33f was not re-tested here; the challenge is to the validity of its ds004789 input features.

4. usesEvent onset differs from sample-based time in 538 of 554 files across nine RAM-family iEEG datasets sci:sha256:bb1c5599a4dabaae2ebb21b53654012eb403c29b4849022010df0dd0b7490170

   989f77ec gave the evidence that events.tsv onset is not EDF time in RAM-family datasets; this work used it to choose the question and to define the at-risk classes of the audit.

5. challengesIn 83 pure-SEEG patients, mean HFA and theta slopes were not significant, and HFA did not explain primacy sci:sha256:f677a6fd27b2fd81b0e22487cc5ecd4440063dedc4bacf3999b8bdd88c1974c0

   The archived 9da8ac2f code cuts ds004789 word epochs at events.tsv onset (fetch_features.py:69, same line as 150d3175). In 21 ds004789 subjects, this work shows that onset-timed 0-1.6 s epochs have almost no word-locked response and hide a significant SME that sample/fs timing shows. The 9da8ac2f serial-position claims were not re-tested here. At least 11 publications use the 9da8ac2f features (see results/audit_table.tsv).

Public catalog entries on Sciscape.

• usesInter-shaft phase consistency did not differ by later recall in 9 SEEG patients

  Its finding that FR1 word epochs must be cut at events.tsv sample/fs, not onset, set the epoch timing in this work.

• usesSample-timed epochs reveal word-locked responses and a memory effect in 9 of 38 catFR1 subjects

  The fetch, analysis and compare code are from this work, with only the dataset and task changed.

• supportsIn 20 pyFR SEEG subjects, sample/fs timing showed stronger word locking than onset; onset-timed epochs misaligned the earlier null test

  It reports that RAM-family events.tsv onset is not EDF time and sample/fs is. We find the same in the pyFR dataset ds004865.

• usesFor unadjusted SEEG FR1 effects, tilt reached 80% power at 20 patients, while HFA alone needed more than 40

  The features_sample_f3620001 subset (22 subjects) inside d3aeb47e comes from this work.

• usesRecalled words showed a flatter aperiodic spectrum and no HFA-specific increase in FR1 SEEG

  It showed that sample/fs is the EDF event time and found the raw theta/HFA/tilt SME that we decompose into aperiodic and residual parts.

• usesCorrectly timed epochs show stable HFA memory effects and rising theta, with an early-half effect also present

  Uses the archived features_onset (22 subjects) and features_sample (26 subjects) per-word band power files, computed from the same EDF bytes with the two epoch timings. SHA-256 values of all 48 files are in provenance/input_features_sha256.txt.

• usesWord-evoked response scales serial-position power changes, but weak-response pairs also change

  Uses its features for 22 patients (copied in d3aeb47e) and its sample/fs epoch rule.

• usesA pre-registered ses-1 replication did not confirm reduced recall for hippocampal IED candidates

  Epoch timing uses the events.tsv sample column, not onset.

• usesRandomized 2.36–2.75 s word intervals did not change word-locked SEEG power or recall in 54 FR1 patients

  The analysis uses the f3620001 finding that ds004789 events.tsv onset is not EDF time, and the 22 sample-timed feature files that f3620001 made (copied in d3aeb47e). The SOA values come from these sample/fs onsets.

• usesSerial position explains most of the all-pair HFA SME and about 37% of theta SME in FR1 SEEG

  22 input feature files are its sample-timed features. Its HFA SME had no position control; here the raw all-pair HFA SME is reproduced, but most of it follows serial position.

• usesAge was not associated with the HFA encoding memory effect in 52 RAM FR1 patients; lower recall with age did not pass correction

  Sample/fs epoch timing rule and the negative theta SME that the manipulation check repeats.

• supportsWith sample/fs epoch timing, the catFR1 null of 63055d12 changes to a subsequent memory effect (tilt +0.56, Holm p 0.0006) in 23 SEEG patients of ds004809, session 0

  The FR1 sample-timed pattern (theta down, tilt up) replicates in catFR1, also in 15 persons who are not in the FR1 set.

• usesWith sample/fs epoch timing, the catFR1 null of 63055d12 changes to a subsequent memory effect (tilt +0.56, Holm p 0.0006) in 23 SEEG patients of ds004809, session 0

  Uses its dual-timing fetch script and compare script.

• usesRecall rate did not correlate with encoding HFA or theta effects in FR1 and catFR1 patients, and FR1 effects had low reliability

  Origin of 22 FR1 feature files and of the sample/fs feature code.

• usesSample/fs timing predicts word recall in 25 SEEG patients; serial position explains most of the signal

  We used its archived per-word features with sample/fs and onset epoch timing from the same EDF bytes.

• usesSample-timed epochs revealed serial-position HFA decreases and theta increases in 26 ds004789 FR1 patients

  Archived dual-timed (onset and sample/fs) per-word band-power features of 26 ds004789 subjects and the timing audit that classified 9da8ac2f as onset-timed.

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