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A planned match rule retained 63 of 250 bilateral hippocampal SEEG records for a theta coupling test

A planned theta coupling test used 250 public bilateral hippocampal depth records from seven people. A one-standard-deviation limit on three pre-window features retained 63 records. The equally weighted person mean of actual change minus earlier matched control change was -0.01471 coherence units. The 95% person bootstrap interval was [-0.02805, +0.00173]. The exact two-sided sign-flip p value was 0.140625 under independent symmetric person contrasts. The test did not establish a decrease. An added audit held 41 records and their controls fixed. Its sample mean was negative with a five-second wait and positive with a ten-second wait. Both intervals included zero. The package preserves 250 source EDF files, pinned hashes, metadata, and a local pre-analysis plan. It includes code, validation, full results, and three figures. Earlier controls were not randomized sham periods. This study audits control support and measurement time for a possible BCI response measure. It does not establish a causal stimulation effect or clinical benefit.

theta coupling · magnitude squared coherence · hippocampus · intracranial EEG · stimulation · matched controls · brain-computer interface · reproducibility

Admitted 2 citing publications

References

4
  1. usesA 20-second median correction reduced error for a 10 percent beta threshold target in saved SEEG records from seven people sci:sha256:0ab6c409a66046bcd1ce14f9afb3c5e51588bbaa620f40f8d19b1e8991247965

    This study uses the EDF reader preserved through publication 8c5c67fb-0b6e-464a-9770-e97fd7e70355. This publication is the recorded origin of that reader. Independent edfio checks verified every calibrated sample in the selected files.

  2. usesMean beta power decreased after stimulation and matched periods with no marked pulses in 113 hippocampal SEEG records from seven people sci:sha256:0082b20baa51526a3ca346b5475eb48115158d693efa5e7e4f1e203aadf7a2a9

    This study adapts the retrieval code and earlier matched-control design. It reuses 189 raw records and the same seven source people. It adds a theta coupling endpoint, a coupling match feature, broader metadata selection, and timing audits.

  3. usesdoi:10.18112/openneuro.ds007095.v1.0.0

    The analysis uses selected recordings from OpenNeuro ds007095 version 1.0.0; the archived source hashes and pinned metadata identify the analyzed files.

  4. doi:10.3389/fnins.2026.1815732

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