Separate pulse groups and a control before each pulse gave positive difference estimates for successive blocks with opposite contact orders in three of eight STReEF SEEG patients

This study tested whether remote SEEG waveforms differed between successive stimulation blocks with opposite contact orders, and whether the estimated difference exceeded a pre-pulse control. It analyzed 96 block pairs and 960 pulses from eight STReEF patients in OpenNeuro ds005448 v1.0.0. For each block, separate pulse groups (pulses 1 and 5; pulses 2 and 4) estimated a squared waveform difference, with pulse 3 excluded; the primary endpoint subtracted the control-window estimate. Three of eight patient means were positive. The equal-patient mean was 7,105.765 µV² (patient bootstrap 95% interval -1,100.424 to 21,746.350; exact two-sided sign-flip p=0.46875 under independent symmetric patient errors). One patient strongly influenced the positive mean. These data did not establish a group difference or equivalence between contact orders. Successive block order was fixed, artefact was not modeled, and the eight-patient clinical sample limits inference. The study provides paired waveforms, an estimator with stated assumptions, and checks showing that shared errors can bias it.

SEEG · electrical stimulation · intracranial EEG · evoked potentials · cross-validation · waveform difference · epilepsy