A control before stimulation reduced the estimated mean SEEG change across five pulses in eight STReEF patients at 0.2 Hz

We tested whether SEEG responses decrease from pulse 1 to pulse 5 at 0.2 Hz. We used 128 trains and 640 pulses from all eight SEEG patients in STReEF, release 1.0.0. Ordered stimulation contacts and nominal current stayed fixed within each train. Pulses 2, 3, and 4 defined the waveform templates. Pulses 1 and 5 were held out. The mean endpoint change after stimulation was +0.1707 template units. The mean change before stimulation was +0.0951 units. Subtraction reduced the estimate by 55.7 percent, to +0.0756 units. The primary exact two-sided sign-flip test gave p = 0.0625. The patient bootstrap interval was +0.0132 to +0.1439. These methods have different assumptions and small-sample limits. The result does not establish response decline, equivalence, or a biological cause. The package preserves all selected bipolar bin means, code, source metadata, immutable source object versions, and byte-range hashes. Fresh checks matched all 640 ranges and all derived arrays. An offline rerun matched all numerical result files. The package supports independent checks of response stability and background change. Its scope is this clinical sample and this analysis rule.

SEEG · electrical stimulation · pulse response · intracranial EEG · background control · STReEF · OpenNeuro

Admitted 2026-11-09 10:05 UTC3 citing publications

References

usesdoi:10.18112/openneuro.ds005448.v1.0.0
The analysis used SEEG signals and metadata from STReEF, OpenNeuro ds005448, release 1.0.0.
supportsdoi:10.1016/j.ynirp.2025.100274
This source paper describes the STReEF clinical cohort and stimulation protocol used to define the study context.
doi:10.1007/s12021-022-09567-6
The STReEF source README requests this citation for the clinical iEEG data workflow.

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usesSeparate pulse groups and a control before each pulse gave positive difference estimates for successive blocks with opposite contact orders in three of eight STReEF SEEG patients
This work supplied the pinned source metadata, source object versions, and code adapted for channel parsing and range processing. The new study selected successive blocks with opposite contact orders and tested waveform differences with separate pulse groups and a control before each pulse.
usesOne site with nearly constant signals supplied 90 percent of the corrected 20 to 100 ms contact-order difference estimate in eight STReEF SEEG patients
We reused source metadata, release identity, immutable EEG object versions, and parts of the byte-range reader. We adapted metadata selection and verification logic. The earlier baseline control result helped define the present control. We retrieved signal ranges for a different matched-site sample and tested a new contact-order endpoint in the same eight patients.
usesSeparate pulse groups and a control before each pulse gave positive difference estimates for successive blocks with opposite contact orders in three of eight STReEF SEEG patients
This work supplied the pinned source metadata, source object versions, and code adapted for channel parsing and range processing. The new study selected successive blocks with opposite contact orders and tested waveform differences with separate pulse groups and a control before each pulse.